Mongolian spots associated with cleft lip

doi:10.1016/0007-1226(89)90072-6

British Journal of Plastic Surgery

Volume 42, Issue 6, November 1989, Pages 625-627

https://doi.org/10.1016/0007-1226(89)90072-6 Get rights and content

Abstract

Of the present series comprising 66 newborns with cleft lip, 13 (20%) had pigmented macules in the labial skin on the lateral side of the cleft. Histological examination using serial sections were performed on 47 cases and showed evidence of dermal melanocytosis in 40 cases (85%) consisting of 33 (70%) without clinically detectable macules and 7 (15%) with obvious pigmented macules. The fusiform cells in the dermis were positive for dopa reaction and anti-melanocyte antibody. The high incidence of dermal melanocytosis is comparable to that of common Mongolian spots in Asian babies.

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Dermal melanocytosis associated with cleft lip
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Circumscribed dermal melanocytosis (Mongolian spot)

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Cited by (6)

The amounts of melanin pigment causing color differences between the vermilion and lip mucosa
2018, Journal of Plastic, Reconstructive and Aesthetic Surgery
Congenital and genetic disorders of hyperpigmentation
1995, Current Problems in Dermatology (United States)
Pigmented skin lesions are often the initial clue to the presence of an underlying disorder or syndrome. In evaluating such conditions, it is helpful to categorize the lesions according to their morphology and distribution. A diagnostic approach is provided, with the general topics consisting of melanocytic nevi, widespread or localized “spotty” pigmentation such as simple lentigines, café-au-lait macules, hyper-pigmentation along the lines of Blaschko, reticulate pigmentation, dermal melanocytosis, dyschromatosis, and other unique pigmentary patterns. Within this framework, we outline and review a variety of congenital and genetic disorders of hyperpigmentation, including giant congenital nevi and neurocutaneous melanosis, the multiple lentigines syndrome, Carney syndrome, and Peutz-Jehgers sywdrome, the neurofibromatoses, the McCune-Albright syndrome, incontinentia pigmenti and other conditions due to genetic mosaicism, dyskeratosis congenita and Fanconi's anemia, nevus of Ota, and many other conditions in which cutaneous pigmentation signals an underlying disorder. Diagnostic criteria and suggested clinical evaluation are provided when applicable.
Cleft lip mongolian spot: Mongolian spot associated with cleft lip
1994, Journal of the American Academy of Dermatology
Background: Mongolian spots in the cleft area of cleft lip have been found in some Japanese children.
Objective: Our purpose was to study the frequency of cleft lip mongolian spot in children with cleft lip of various severity.
Methods: Sixty-six babies with unilateral cleft lip were divided into three groups: namely, those with microform cleft lip (10 subjects), incomplete cleft lip (30 subjects), and complete cleft lip (26 subjects). The incidence of cleft lip mongolian spot in the three groups was studied.
Results: Thirty-six babies (55%) had a cleft lip mongolian spot. The mongolian spot was observed in no patients with microform cleft lip, in 18 patients (60%) with incomplete cleft lip, and in 18 patients (69%) with complete cleft lip.
Conclusion: Cleft lip mongolian spot appears in high incidence when the cleft goes beyond the vermilion border.
A comprehensive review of Mongolian spots with an update on atypical presentations
2018, Child's Nervous System
Acquired and Congenital Dermal Hypermelanosis
2007, The Pigmentary System: Physiology and Pathophysiology: Second Edition
Association of dermal melanocytosis with lysosomal storage disease: Clinical features and hypotheses regarding pathogenesis
2003, Archives of Dermatology

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Mongolian spots associated with cleft lip

Abstract

Dermal melanocytosis associated with cleft lip

Archives of Dermatology

The neural crest in abnormalities of the face and brain

Circumscribed dermal melanocytosis (Mongolian spot)