Determination of enzymes and degradation products of glycosaminoglycan metabolism in the serum of healthy and varicose subjects

doi:10.1016/0009-8981(72)90105-2

Clinica Chimica Acta

Volume 42, Issue 2, December 1972, Pages 399-408

https://doi.org/10.1016/0009-8981(72)90105-2 Get rights and content

Abstract

The activity of 3-glycosaminoglycan hydrolases (β-glucuronidase, β-N-acetyl-glucosaminidase and arylsulfatase) was greatly increased in the serum of 26 varicose patients compared with that in 24 healthy subjects (p < 0.001); in addition, this activity increases in relation to the severity of the varices.

Glycosaminoglycan and glycoprotein components are also significantly increased in the serum of 25 varicose patients compared with that of 25 healthy subjects; p < 0.001 for sialic acids and polysaccharides, p < 0.01 for sulfates and p < 0.02 for hexoses, hexosamines and fucose. There was however no significant difference in relation to the severity of the varices. These results are examined in terms of the pathogenesis of venous tissue and regarding the possibilities in clinical chemistry.

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Determination of enzymes and degradation products of glycosaminoglycan metabolism in the serum of healthy and varicose subjects

Abstract

J. Biol. Chem.

Anal. Biochem.

Clin. Biochem.

Biochim. Biophys. Acta

Angiologica

Angiologica

Clin. Sci.

Angiologica

Brit. Med. J.

Med. Welt

Sovetshaya Meditsina

Biochem. J.

Choix de Techniques de Biochimie Clinique

Acta Chem. Scand.

Angiologica