Rapid communicationIncreased hippocampal acetylcholine release during a working memory task
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2017, Behavioural Brain ResearchCitation Excerpt :The decreased acetylcholine levels found in our study may be due to decreased CRH transcript levels. Since increased acetylcholine release was reported during working memory performance [75] and hippocampal cholinergic signaling is associated with cognition [76], the memory deficits observed in our study could be due to decreased cholinergic signaling in combination with decreased CRH levels. Impaired memory in the stressed mice could also be partly due to elevated levels of IL-1β levels because IL-1β and cognition are negatively correlated [77,78].
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