MinireviewMitochondrial pyruvate transport and its hormonal regulation
References (61)
- et al.
Control of hepatic mitochondrial CO2 fixation by glucagon, epinephrine and cortisol
J. biol. Chem.
(1969) Transport of pyruvate and lactate in yeast mitochondria
Biochim. biophys. Acta
(1977)- et al.
Substrate anion transport in mitochondria
Biochimie
(1973) - et al.
The stimulatory effect of glucagon and dibutyryl cyclic AMP on ureogenesis and gluconeogenesis in relation to mitochondrial ATP content
FEBS Lett.
(1977) - et al.
Pyruvate transport in tumour-cell mitochondria
Biochim. biophys. Acta
(1977) The regulation of liver pyruvate kinase by phosphorylation-dephosphorylation
Current Topics Cell. Reg.
(1978)- et al.
Homeostatic regulation of cellular energy metabolism
TIBS
(1978) - et al.
Effects of l-lactate, pyruvate, fructose, glucagon, epenephrine and adenosine 3'-5'-monophosphate on gluconeogenic intermediates in the perfused rat liver
J. biol. Chem.
(1969) - et al.
The hormonal control of gluconeogenesis by regulation of mitochondrial pyruvate carboxylation in isolated rat liver cells
J. biol. Chem.
(1975) Pyruvate transport across mitochondrial and plasma membranes
Inhibition of mitochondrial pyruvate transport by phenylpyruvate and α-keto-isocaproate
Biochim. biophys. Acta.
Mechanisms of hormonal control of gluconeogenesis
Metabolism
he involvement of mitochondrial pyruvate transport in the pathways of gluconeogenesis from serine and alanine in isolated rat and mouse liver cells
FEBS Lett.
Inhibited respiration and ATPase activity of rat liver mitochondria under conditions of matrix condensation
FEBS Lett.
On the mechanism of uncoupler dependent inhibition of acylcarnitine oxidation by rat liver mitochondria
FEBS Lett.
Pyruvate and acetoacetate transport in mitochondria: a reappraisal
J. biol. Chem.
The transport of pyruvate in rat liver mitochondria
FEBS Lett.
The transport of monocarboxylic oxoacids in rat liver mitochondria
FEBS Lett.
Substrate regulation of the pyruvate transporting system in rat liver mitochondria
FEBS Lett.
On the kinetics and substrate specificity of the pyruvate translocator in rat liver mitochondria
Biochim. biophys. Acta
Glucagon induced stimulation of 2-oxoglutarate metabolism in mitochondria from rat liver
FEBS Lett.
The mitochondrial pyruvate carrier, its exchange properties and its regulation by glucagon
FEBS Lett.
Hormonal regulation of liver mitochondrial pyruvate carrier in relation to gluconeogenesis and lipogenesis
FEBS Lett.
Preparation and properties of mitochondria from lactating rat mammary gland in particular relation to lipogenesis
Int. J. Biochem.
Glucagon treatment stimulates the metabolism of hepatic submitochondrial particles
J. biol. Chem.
Studies on the regulation of gluconeogenesis in isolated rat liver cells by epinephrine and glucagon.
J. biol. Chem.
Selective inhibition of pyruvate and lactate metabolism in bovine epididymal spermatozoa by dinitrophenol and α-cyano-3-hydroxycinnamate
Archs Biochem. Biophys.
Glucagon stimulation of mitochondrial respiration
J. biol. Chem.
Glucagon stimulation of citrulline formation in isolated hepatic mitochondria
Archs Biochem Biophys.
Glucagon stimulation of mitochondrial ATPase and potassium ion transport
FEBS Lett.
Cited by (83)
Transport of haloacids across biological membranes
2016, Biochimica et Biophysica Acta - BiomembranesCompartmentalizing metabolic pathway in Candida glabrata for acetoin production
2015, Metabolic EngineeringCitation Excerpt :However, strain CmA4 suffered from weak cell growth, exhibiting a slight decrease from 10.23 to 9.85 g/L, and also showed slightly lower production of byproducts such as ethanol (2.16 g/L), acetate (0.71 g/L), and glycerol (1.16 g/L) (Table 4). In yeasts, mitochondrial pyruvate is essential for glucose oxidation, gluconeogenesis, lipogenesis, and amino acid metabolism (Halestrap et al., 1980), during which α-ketoglutarate could directly reflect the dynamics of the TCA cycle (Liu et al., 2007b). In strain CmA4, acetoin formation competed for pyruvate with pyruvate dehydrogenase (PDH), and subsequently weakened the carbon flux of pyruvate into the TCA cycle, leading to 25.1% and 3.7% decrease in the levels of α-ketoglutarate and cell growth, respectively, when compared with those of strain CmA3 (Table 4).
Lack of association between MPC2 variants and schizophrenia in a replication study of Han Chinese
2013, Neuroscience LettersCitation Excerpt :The detailed summary is shown in Table 3. Previous study has indicated that mitochondrial pyruvate carrier is essential for several major pathways of mammalian carbohydrate, fat, and amino acid metabolism [3], and metabolic pathway disturbances have been found to be involved in psychiatric disorders such as SCZ [7,12]. The malfunction of glucose metabolism may be a causative factor for SCZ [4,6].
The mitochondrial pyruvate carrier: Has it been unearthed at last?
2012, Cell MetabolismCitation Excerpt :Transport is mediated by the mitochondrial pyruvate carrier (MPC) whose existence was confirmed in 1974 by the discovery of a potent and specific inhibitor, α-cyano-4-hydroxycinnamate (CHC). Subsequently, its substrate and inhibitor specificity and roles in metabolism were extensively investigated (Halestrap et al., 1980). Transport of most metabolites across the inner mitochondrial membrane (IMM) involves members of the mitochondrial carrier family (MCF; 53 members in humans), which are usually 30–35 kDa in size and have six transmembrane domains (TMDs) (Palmieri and Pierri, 2010).
Phosphoenolpyruvate metabolism in Jerusalem artichoke mitochondria
2007, Biochimica et Biophysica Acta - BioenergeticsCitation Excerpt :The mitochondrial and cytosolic PK reactions, monitored at 0.1 mM PEP and 0.25 mM ADP, were also compared with respect to their sensitivity to a variety of compounds, including MALO (10 mM), oxalate (10 mM), arsenite (1 mM), sulphite (2 mM), inhibitors of succinate, lactate, pyruvate and malate dehydrogenase respectively. The thiol reagent mersalyl (0.1 mM), benzentricarboxylic acid (BTA, 1 mM), the metal complexing agent bathophenanthroline (BF, 0.1 mM), α-cyano-4-hydroxycinnamate (α-CCN-, 1 mM) carboxyatractyloside (CAT, 10 μM), inhibitors of some mitochondrial carriers [34,35], OLIGO (5 μM), an inhibitor of ATP synthase and alanine (ALA, 5 mM) were also used (Fig. 3B). The inhibition profiles proved to differ significantly one from another.
Identification and characterisation of a new class of highly specific and potent inhibitors of the mitochondrial pyruvate carrier
2005, Biochimica et Biophysica Acta - BioenergeticsCitation Excerpt :We have suggested previously that this may reflect the presence of a hydrophobic binding pocket on the matrix surface of the carrier. The inhibitors may reach this site by binding to the outer face of the carrier, which then undergoes a conformational change translocating the inhibitor into a hydrophobic matrix facing binding pocket [2,10]. Alternatively, the inhibitor may be sufficiently lipid soluble to accumulate within the bilayer and then diffuse laterally into a binding site on the carrier.