Relationship between serum lipids, lipoproteins and pseudocholinesterase during organophosphate poisoning in rabbits
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Monocrotophos augments the early alterations in lipid profile and organ toxicity associated with experimental diabetes in rats
2011, Pesticide Biochemistry and PhysiologyCitation Excerpt :HDL-C is mainly synthesized in the liver and intestinal cells and it plays an important role in cholesterol efflux from tissues and carries it back to the liver for removal as bile acids, where the reduced levels are associated with an increased risk for coronary artery disease [36]. It has been previously suggested that organophosphates may phosphorylate and inhibit the hydroxy-methylglutaryl CoA reductase, the key enzyme in cholesterol production [30]. In the present study, STZ rats revealed slight increase in HDL-C compared to control rats, while administration of MCP did not affect the HDL-C.
Organophosphorus pesticides as food chain contaminants and type 2 diabetes: A review
2010, Trends in Food Science and TechnologyCitation Excerpt :In turn, the increased level of plasma TGs causes lowered HDL-C levels and increased sdLDL (Carmena, 2005). In agreement of these findings, previous studies have demonstrated a significant increase in serum TG concentrations in experimental animals treated with different insecticides, including the organophosphate Dichlorvos (Ryhanen et al., 1984), malathion (Rezg et al., 2010), Diazinon (Ibrahim & El-Gamal, 2003) and carbamate Furadan (Gupta et al., 1986). This elevation of serum or plasma TG has been attributed to an inhibition of the lipase enzyme activity of both the hepatic TG and plasma lipoproteins (Musliner, Herbert, & Kingston, 1979; Goldberg et al., 1982).
Comparative study on pesticide mixture of organophosphorus and pyrethroid in commercial formulation
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