The etiology of gastrointestinal perforations in the newborn
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Cited by (238)
Bowel scintigraphy identifies segmental dysmotility prior to stoma closure
2021, Journal of Pediatric Surgery Case ReportsSegmental absence of intestinal musculature with metachronous bowel perforations in an infant
2018, Journal of Pediatric Surgery Case ReportsFocal intestinal perforation in late preterm and term neonates with hypoxic ischemic encephalopathy
2015, Journal of Pediatric Surgery Case ReportsDiseases of the Pediatric Stomach and Duodenum
2014, Textbook of Gastrointestinal Radiology: Volumes 1-2, Fourth EditionIntestinal muscularis propria increases in thickness with corrected gestational age and is focally attenuated in patients with isolated intestinal perforations
2014, Journal of Pediatric SurgeryCitation Excerpt :Although this study has limited power to determine the significance of risk factors for perforation, we observed that a higher proportion of babies with IIP had received antenatal NSAIDs and steroids, postnatal steroids and vasopressors, and initiation of enteral feeds and CPAP, when compared to controls. Previous studies, including a large data set from the Pediatrix Medical Group and several case series, have suggested possible antenatal risk factors including anatomic abnormalities (low birth weight, congenital diverticula, omphalomesenteric remnants, intussusceptions, compression from intraluminal meconium), physiologic deficiencies (hypoxia, ischemia), infections (chorioamnionitis), and medications (NSAIDs, steroids) [10,11,16,18,25,28–34]. Antenatal NSAIDs are commonly used as first-line agents in tocolysis (indomethacin), as well as for analgesia (ketorolac, ibuprofen), while steroids are used to accelerate fetal lung maturity and reduce mortality from respiratory distress syndrome [35,36].
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Attending Surgeon, The Children's Hospital of Michigan; Associate Surgeon, Harper Hospital; Instructor in Surgery, Wayne State University School of Medicine.