Abnormal distribution of nerve terminals in infantile hypertrophic pyloric stenosis☆
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Cited by (42)
Congenital and acquired pylorostenosis in children
2017, Pediatria PolskaEfficacy of Medical Treatment for Infantile Hypertrophic Pyloric Stenosis: A Meta-analysis
2016, Pediatrics and NeonatologyCitation Excerpt :The mechanism of atropine sulfate in IHPS therapy mainly involves a cholinergic blocking agent with potent antimuscarinic activity that decreases peristaltic contractions by relaxing the pyloric smooth muscles.29 The effective range varies widely, perhaps because of the alterations in the muscarinic receptor sensitivity of the muscle,29 variations in drug clearance, compromised blood flow secondary to pyloric spasm, lack of nitric oxide synthase, and poor innervation of the pyloric circular musculature.23,24,30 The pharmacologic activity of IV atropine is 2–3 times greater than that of the oral form, with faster response to the effective IV dose.
Hypertrophic Pyloric Stenosis
2012, Pediatric Surgery, 2-Volume Set: Expert Consult - Online and PrintHypertrophic Pyloric Stenosis
2012, Pediatric SurgeryLocalization and neurochemical characteristics of the extrinsic sympathetic neurons projecting to the pylorus in the domestic pig
2012, Journal of Chemical NeuroanatomyCitation Excerpt :Despite numerous studies, the etiology of pylorostenosis still remains unknown. However, experiments with use of immunocytochemical and molecular biology techniques have suggested, that disturbances in the innervation of the pyloric wall may contribute to the pathogenesis of IPHS (Kobayashi et al., 1994; Malmfors and Sundler, 1986; Okazaki et al., 1994; Vanderwinden et al., 1992). The first aim of the present study was to localize the extrinsic sympathetic postganglionic perikarya innervating the pylorus in the domestic pig by usage of the fluorescent retrograde tracing method with Fast Blue neuronal tracer.
Infantile Hypertrophic Pyloric Stenosis: Epidemiology, Genetics, and Clinical Update
2011, Advances in PediatricsCitation Excerpt :Abnormalities in hormonal control, extracellular matrix, smooth muscle fibers, growth factors, interstitial cells of Cajal, and pyloric innervations have been implicated in the pathogenesis of IHPS. The muscular layer of the pylorus in IHPS is reportedly characterized by abnormal distribution of nerve terminals [5], reduced intramuscular nerve supporting cells [6], altered peptidergic innervation [7], altered nitric oxide production [8], ultrastructural abnormalities of enteric nerves and the interstitial cells of Cajal [9], and increased insulin-like growth factor production [10]. This constellation of abnormalities leads to failure of the pyloric muscle to relax, increased synthesis of growth factors, and subsequent hypertrophy [11].
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Presented at the 26th Annual Meeting of the Pacific Association of Pediatric Surgeons, Cairns, Queensland, Australia, May 9–14, 1993.