A reproducible model of acute hepatic failure by transient ischemia in the pig☆
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Cited by (45)
Development of a porcine model of post-hepatectomy liver failure
2011, Journal of Surgical ResearchCitation Excerpt :To prove the functional support of liver support devices in POLF, it is necessary to establish a standardized hepatic failure model, which closely correlates to the real clinical setting and can be reproduced in large animals. The animal models of POLF include devascularization procedures [3], partial or total hepatectomy [4], partial or complete devascularisation [5], with or without portocaval shunt [6, 7]. Terblanche and Hickman [8], with some later additions by others, have established a series of requirements for an ideal model of fulminant hepatic failure (FHF).
Rabbit hemorrhagic viral disease: Characterization of a new animal model of fulminant liver failure
2003, Journal of Laboratory and Clinical MedicineCitation Excerpt :Although many animal models of FLF are available, most do not meet all these criteria.13,14 Models based on hepatectomy or complete ischemia5,6 lack the potential for reversibility or recovery and do not produce an environment complicated by the release of inflammatory mediators and products of liver-cell necrosis. Agents such as acetaminophen/buthionine sulfoximine or galactosamine7,10,11 produce clinical relevant features, including hypoglycemia, encephalopathy and increased concentrations of liver enzymes, but may require repeated administration, close monitoring of drug levels, and supportive therapy; several factors may cause variability from experiment to experiment.
Increased intracranial pressure in a porcine model of fulminant hepatic failure using amatoxin and endotoxin
2001, Journal of HepatologyAnimal models of fulminant hepatic failure: Need to test liver support devices
2001, Digestive and Liver DiseasePorcine model of fulminant hepatic failure treated by liver transplantation
2000, Transplantation Proceedings
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Supported by The Foundation for Medical Research FUNGO, The Netherlands.