Further evidence validating adjuvant arthritis as an experimental model of chronic pain in the rat
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Factors mediating pain-related risk for opioid use disorder
2021, NeuropharmacologyCitation Excerpt :One study found that arthritic rats self-administered IV morphine at a lower rate than control animals, an effect that was reversed by indomethacin, suggesting that inflammatory pain reduces the reinforcing effects of opioids (Lyness et al., 1989). Conversely, oral intake of fentanyl was shown to increase with the development of CFA-induced arthritis in rats, and intake mirrored the arthritic process (Colpaert et al, 1982, 2001). Additionally, CFA-induced arthritis attenuated low dose heroin self-administration under both FR and PR schedules of reinforcement in rats, whereas high-dose heroin self-administration approximately doubled under the FR schedule but did not change under the PR schedule (Hipólito et al., 2015).
Pain, negative affective states and opioid-based analgesics: Safer pain therapies to dampen addiction
2021, International Review of NeurobiologySensitized brain response to acute pain in patients using prescription opiates for chronic pain: A pilot study
2019, Drug and Alcohol DependenceCitation Excerpt :Many individuals continue to use opiates due to concerns about pain (Barth et al., 2013). Previous work supported the idea that the presence of pain was protective against the development of an addiction phenotype (Colpaert et al., 1982, 2001; Lyness et al., 1989; Ozaki et al., 2004), however there is growing evidence that this is not the case (Ewan and Martin, 2013; Hou et al., 2015; Zhang et al., 2014) and epidemiological studies find evidence of misuse and addiction among individuals with chronic pain (Vowles et al., 2015). This study provides possible targets for treating the pain that is associated with chronic opiate usage.
Evaluation of anti-arthritic potential of Trigonella foenum graecum L. (Fenugreek) mucilage against rheumatoid arthritis
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