Lecithin-cholesterol acyltransferase and lipid transfer protein activities in liver disease
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Role of lipids in pathophysiology, diagnosis and therapy of hepatocellular carcinoma
2020, Biochimica et Biophysica Acta - Molecular and Cell Biology of LipidsCitation Excerpt :Lecithin-cholesterol acyltransferase (LCAT), which is a key enzyme for cholesterol esterification in plasma, showed a progressive decline with hepatocellular damage [77]. Serum cholesterol and LCAT activity were low in liver cirrhosis patients and HCC [77]. Thus, total cholesterol and cholesteryl ester levels seem to decline in serum of liver cirrhosis patients.
Associations of systemic sphingolipids with measures of hepatic function in liver cirrhosis are related to cholesterol
2017, Prostaglandins and Other Lipid MediatorsCitation Excerpt :PUFA CEs are markedly low in the patients with more advanced liver injury analyzed in the present study [9]. LCAT is the major enzyme for esterification of cholesterol with PUFAs in serum, and is found reduced in patients with liver cirrhosis [25,26,35]. CE species formed by LCAT [27] are, however, mostly not related to Child-Pugh or MELD score.
Systemic saturated lysophosphatidylcholine is associated with hepatic function in patients with liver cirrhosis
2016, Prostaglandins and Other Lipid MediatorsCardiovascular risk, lipidemic phenotype and steatosis. A comparative analysis of cirrhotic and non-cirrhotic liver disease due to varying etiology
2014, AtherosclerosisCitation Excerpt :Therefore it may often be depressed in advanced cirrhosis with paralleling increased values of free CH and lecithin and corresponding decreases in CH ester and lysolecithin [129,143]. As a further consequence of reduced activities of LCAT and hepatic lipase [129,134], remodeling of VLDL to LDL is impaired, esterified/free CH ratio is reduced, HDL and LDL are poor in CH ester and proportionally enriched in TG and PL [15,129,143,144]. In vitro studies in cirrhotic patients have shown low HTGL activity, which account for impaired hepatic removal of TG and PL from lipoproteins [15].