Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
Volume 247, Issue 2, April 1991, Pages 241-257
Genetic and environmental factors causing variation in drug response
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Associations between CYP3A4, CYP3A5 and SCN1A polymorphisms and carbamazepine metabolism in epilepsy: A meta-analysis
2021, Epilepsy ResearchCitation Excerpt :Furthermore, the sensitivity analysis also effectively abrogated the heterogeneity but did not influence the present results (supplemental Fig. S22g). With the development of pharmacogenomics, it has been shown that the variability in individual response to antiepileptic drugs depends not only on non-genetic factors (i.e., age, environment and concomitant medications), but also on genetic factors (Vesell, 1991). In a previous study, it was found that genetic factors accounted for 20–95 percent of the factors of individual differences in drug efficacy (McLeod and Evans, 2001).
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Copyright © 1991 Published by Elsevier B.V.