Verruciform xanthoma in a bone marrow transplant recipient

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Abstract

The verruciform xanthoma is an uncommon benign condition of uncertain cause that affects either mucosa or, less commonly, skin. Most lesions are solitary, and most have been reported to involve the oral mucosa. In some instances, chronic damage to the lesional site has been identified. This report describes a verruciform xanthoma that developed on the lower vermilion zone of the lip of a young person who had undergone allogeneic bone marrow transplantation for acute lymphoblastic leukemia. To our knowledge, this is the first reported case of this lesion occurring in a bone marrow transplantation patient. We speculate that immunologically mediated damage to the patient's epithelium in this area may be related to the pathogenesis of the lesion.

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    a

    Associate Professor, Section of Oral and Maxillofacial Surgery, and Oral Pathology, College of Dentistry.

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    Clinical Professor, Departments of Internal Medicine and Pediatrics, College of Medicine.

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