Copulatory behavior and hypothalamic estrogen and progestin receptors in chronically insulin-deficient female rats
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Cited by (19)
Reduced sexual motivation of diabetic female rats: Restoration with insulin
2021, Hormones and BehaviorDoes Chronic Hyperglycemia Affect Female Rat Sexual Behavior? Differences in Paced and Non-Paced Mating
2019, Journal of Sexual MedicineCitation Excerpt :Also, the time that the female spends in the compartment where the male is located and the time of interaction between subjects have been used as indicators of sexual motivation.52 Several studies53–60 have evaluated the female rat sexual behavior in a model of DM1 produced by streptozotocin (2-deoxy2-[3-methyl-3-nitrosourea]-1D-glucopyranose [STZ]), a selective cytotoxic drug of pancreatic β cells (responsible for insulin production),61 administered in adulthood and characterized by severe hyperglycemia, with glucose values >400 mg/dL, and hypoinsulinemia.62 These studies have used OVX females exogenously treated with steroid hormones, because, after administration of STZ in adulthood, there is a drastic reduction in the number of spontaneous proestrus.63,64
Reduced Lordosis and Enhanced Aggression in Paced and Non-Paced Mating in Diabetic Female Rats
2018, Journal of Sexual MedicineCitation Excerpt :Clinical54,55 and preclinical56–58 studies have proposed nociception and changes in the vagina59 and clitoris60 as possible reasons mediating sexual inhibition. Various investigators have shown that peripheral27–29,31 and intracerebroventricular32 insulin administration and an artificial pancreas33 completely restore the inhibited lordosis produced by STZ injection.27–29,31–33 Our observations differ from these findings, particularly in the LQ, where glargine lacked an effect.
Sex steroid hormones in diabetes-induced sexual dysfunction: Focus on the female gender
2009, Journal of Sexual MedicineThe effect of diabetes on α<inf>2</inf>-adrenergic receptor activity in the reproductive centers of the female rat brain
2000, American Journal of Obstetrics and GynecologyCitation Excerpt :Furthermore, in light of compelling evidence that insulin maintains hypothalamic estrogen receptor levels11 and also insulin facilitates central noradrenergic neurotransmission, future study might consider whether insulin replacement could correct diabetes-induced adrenergic deficits.