Parenteral toxicity studies with benzyl alcohol
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Cited by (41)
Gasping syndrome, 1982
2021, History of Modern Clinical ToxicologyForced degradation study of racecadotril: Effect of co-solvent, characterization of degradation products by UHPLC-Q-TOF-MS/MS, NMR and cytotoxicity assay
2016, Journal of Pharmaceutical and Biomedical AnalysisCitation Excerpt :The most characteristic peak at δ 10.32 (s, 1H) of carboxylic acid and loss of a peak at δ 3.73 (s, 3H) of methyl group confirms the structure of DP 2 as 2-(2-benzyl-3-mercaptopropanamido) acetic acid. The toxicity of degradation product, DP 1(benzyl alcohol) was extensively studied and reported in the literature [15–22]. Hence, cytotoxicity tests for the isolated degradation products DP 2 and DP 5 were evaluated in the present study.
Potential confounding effects of benzyl alcohol as a formulation excipient support the elimination of the abnormal toxicity test from pharmacopoeias
2015, Regulatory Toxicology and PharmacologyCitation Excerpt :The intravenous LD50 of benzyl alcohol was reported to be 3.00 mmol/kg which equals to 38 mg/kg (Chvapil et al., 1962). Kimura et al. (1971) mentioned that rapid injection (1 mL/5 s) of 0.9% benzyl alcohol in saline was non-lethal at 480 mg/kg in Swiss-Webster female mice. Montaguti et al. (1994) determined, in three inbred mouse strains (CD2F1, B6D2F1 and C57BL/6N), the acute intravenous LD50 of benzyl alcohol to be between 100 and 400 mg/kg.
Fragrance material review on benzyl alcohol
2012, Food and Chemical ToxicologyCitation Excerpt :A solution of 0.9% benzyl alcohol could be given i.v. to rats slowly with no fatalities to 40 ml/kg. After rapid injection, the LD50 in rats was 33.4 ml/kg (0.314 g/kg) (Kimura et al., 1971). An acute intravenous study on a group of solvents, including benzyl alcohol, was determined in three inbread mouse strains (CD2F1, B6D2F1, and C57BL16N).
A toxicological and dermatological assessment of aryl alkyl alcohols when used as fragrance ingredients
2012, Food and Chemical ToxicologyEfficacy of intravascular catheter lock solutions containing preservatives in the prevention of microbial colonization
2011, Journal of Hospital InfectionCitation Excerpt :The rejection of preservatives stems from reports of 16 neonatal deaths related to the use of benzyl alcohol (0.9%) in catheter lock solutions.18 Catheter lock solutions containing benzyl alcohol are not recommended for use in neonates, but animal studies suggest that the infusion of as much as 30 mg of 0.9% benzyl is safe in adults.22 Parabens has not been shown to manifest any clinical side-effects when used as a preservative in lock solution, although some studies have shown that parabens can upregulate specific genes in a manner similar to oestradiol.23
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Present address: Department of Pharmacology, University of Louisville, Louisville, Kentucky.