Chondroblastoma

doi:10.1016/0046-8177(93)90107-R

Human Pathology

Volume 24, Issue 9, September 1993, Pages 944-949

https://doi.org/10.1016/0046-8177(93)90107-R Get rights and content

Abstract

Chondroblastoma of the bone is a benign tumor that has well-characterized radiographic and histologic features. It tends to affect the epiphyseal ends of long bones in men during the second and third decades of life. The tumor is located more frequently at other sites in older patients. The treatment of choice is complete curettage with bone grafting, which in our series provided local control in 82% of patients at 2 years' follow-up. Recurrent tumors usually can be treated in the same manner.

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Cited by (125)

Immunohistochemical analysis of 36 cases of chondroblastomas: A single institutional experience
2020, Annals of Diagnostic Pathology
Citation Excerpt :
It is defined as a benign, chondroid producing neoplasm, composed of immature chondrocytes (chondroblasts), typically arising in the epiphyses or apophysis of immature skeleton [1]. Most cases occur in adolescent and young adults, frequently in males, involving the long bones of the lower extremities [2]. Rarely, this tumor occurs in the bones of craniofacial skeleton, hands and feet, in older patients [2,3].
Chondroblastoma is a relatively uncommon, primary benign bone tumor, frequently identified in young individuals. Despite its classical radiologic and histopathological features, at times, it is fraught with a diagnostic challenge, especially differentiating it from a giant cell tumor of bone (GCTB); an osteosarcoma and a chondrosarcoma. Lately, few studies have shown the diagnostic utility of immunohistochemical (IHC) expression DOG1 antibody in chondroblastomas. The present study was undertaken to evaluate IHC expression of S100 protein, DOG1 and p63 in 36 chondroblastomas.
From January 2013 to July 2019 (6-year duration), 106 chondroblastomas were diagnosed, with IHC staining performed in 36 cases. Conventional Hematoxylin and Eosin stained microsections and IHC stained sections were reviewed in 36 cases. IHC staining of p63 (intranuclear), S100 protein (nuclear and cytoplasmic) and DOG1 (cytoplasmic membranous) was recorded in various cases.
Seventy-four tumors occurred in males and 32 in females, within age-range of 7–55 years (average = 18.6), frequently in tibia (33/106; 31.1%), followed by femur (26, 24.5%) humerus (22, 20.7%), calcaneum (5) and scapula (4). IHC staining for S100P was positive in 33/36cases (91.7%); DOG1 in 16/19 (84.2%) cases and p63 in 10/15cases (66.6%). DOG1 immunostaining was negative in 25 various other tumors. Sensitivity and specificity for S100P, DOG1and p63 in chondroblastomas was (91.6%, 59.3%); (84.2%, 100%) and (66.6%, 46.6%), respectively. P63 was positively expressed in 15/27 (55.5%) GCTBs.
S100 protein and DOG1 can be utilized for a confirmatory diagnosis of a chondroblastoma, especially for differentiating it from its other differentials, such as GCTB, in view of certain associated therapeutic implications. P63 is not useful in that scenario.
Bone Lesions
2020, Gnepp's Diagnostic Surgical Pathology of the Head and Neck, Third Edition
Chondroblastoma: An evaluation of the recurrences and functional outcomes following treatment
2018, Acta Orthopaedica et Traumatologica Turcica
Citation Excerpt :
The most common sites of localization are the proximal tibia or femur, distal femur and the proximal humerus.2 The tumor may also be seen in the bones of the hand, the foot, the skull or in the facial bones.3 Most of the patients present with local pain and upon physical examination, tenderness and limited range of motion are observed.4
Chondroblastoma is a benign aggressive tumor which needs surgical treatment and has a recurrence rate up to 35%. Extended (aggressive) curettage is the mainstay of treatment and local adjuvants have been reported to decrease the recurrence rate.
The recurrence rates and the functional results of 14 patients who were treated in our institution and 2 other patients who were treated elsewhere between the years 2004–2016 were evaluated. Seventeen cases (13 male, 3 female; mean age: 17.1 [range: 13 to 32] years) who had been diagnosed, treated and followed up in our hospital between 2004 and 2016 were evaluated in terms of recurrence rates and functional outcomes. The average follow-up period was 41.6 (range: 12 to 132) months.
Five cases of recurrence were observed. Two cases had undergone their primary treatment in another institution. Seven cases were performed curettage alone whereas nine others were administered adjuvant treatments. One of the five recurrence patients was advised to undergo disarticulation. Another was treated with curettage and grafting and the remaining three patients with curettage and cementing. No recurrence was observed in their follow-up period. Their mean MSTS score was 27.3 (range: 4 to 30) over a maximum of 30 points and their functional results were good.
Chondroblastoma is a tumor with high recurrence rates in the post-treatment period. However, good functional outcomes can be achieved with early diagnosis and appropriate treatment even after recurrence.
Level of evidence: Level IV, therapeutic study.
Diagnostic Pathology: Pediatric Neoplasms
2018, Diagnostic Pathology: Pediatric Neoplasms
Diagnostic Pathology: Cytopathology
2018, Diagnostic Pathology: Cytopathology
Total Calcanectomy and Bilateral Iliac Bone Autograft Reconstruction for the Treatment of Calcaneal Chondroblastoma Involving a Secondary Aneurysmal Bone Cyst: A Case Report and Literature Review
2020, Journal of Foot and Ankle Surgery
Chondroblastoma is a rare, benign, cartilaginous-derived tumor accounting for ∼1% to 2% of all primary bone tumors and almost 9% of all benign bone tumors. In this case report, we describe a patient with chondroblastoma and a secondary aneurysmal bone cyst, with the adjacent talus being mildly affected. The initial diagnosis was giant cell tumor and was then confirmed after computed tomography–assisted biopsy. We performed a total calcanectomy via bilateral structural iliac bone autografting to relieve pain and reconstruct the loadbearing function because of the presence of extensive lesions. The patient was pain free and expressed satisfaction with postsurgical dorsiflexion and plantarflexion function at the 60-month follow-up visit. Radiographic images showed that the autografted iliac bone was completely healed, with no evidence of local recurrence.

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^∗: Visiting clinician in the Section of Surgical Pathology.

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Original contributionChondroblastoma

Abstract

Hum Pathol

Unni KK: Bone Tumors: General Aspects and Data on 8,542 Cases

Bone sarcoma: The primary malignant tumors of bone and the giant cell tumor

Surg Gynecol Obstet

Neoplastic Diseases: A treatise on Tumors

Epiphyseal chondromatous giant cell tumors of the upper end of the humerus

Surg Gynecol Obstet

Benign chondroblastoma of bone: A reinterpretation of the so-called calcifying or chondromatous giant cell tumor

Am J Pathol

Chondroblastoma: A clinical and radiological study of 104 cases

Skeletal Radiol

Chondroblastoma of bone: A critical review

Clin Orthop

Chondroblastoma of bone: A clinicopathologic and electron microscopic study

Cancer

Chondroblastoma of the skull and facial bones

Am J Clin Pathol

Original contribution
Chondroblastoma