Original contributionImmunolocalization of aromatase and other steroidogenic enzymes in human breast disorders
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Steroid metabolism in breast cancer: Where are we and what are we missing?
2018, Molecular and Cellular EndocrinologyCitation Excerpt :The metabolism of DHEA in breast cancer tissue may well depend on the relative expression levels and enzymatic activities of 3βHSD and 17βHSD5. Considering the high concentrations of DHEA observed in breast cancer tissue (Honma et al., 2011), the high levels of 17βHSD5 expression (Lin et al., 2004; Shibuya et al., 2008; Oduwole et al., 2004; Jansson et al., 2006) and low 3βHSD expression (Sasano et al., 1994), it is likely that in many cases DHEA may be preferentially converted to 5-adiol. The relative contributions of 5-adiolS and DHEA to the intratumoral pool of 5-adiol, however, is yet to be elucidated.
The intracrinology of breast cancer
2015, Journal of Steroid Biochemistry and Molecular BiologyCitation Excerpt :In humans there are two enzymes known to be capable of this reaction, 3βHSD1 and 3βHSD2. This conversion of steroids by 3βHSDΔ4-5 isomerase has been reported in breast tissue [20] and up to 33% of breast cancer tissues [16,21]. Following the 3βHSDΔ4-5 isomerisation of steroids, three main factors regulate the equilibrium of intracrine steroid metabolism.
The advantages of co-culture over mono cell culture in simulating in vivo environment
2012, Journal of Steroid Biochemistry and Molecular BiologyCitation Excerpt :In this chapter, we will summarize the advantages of co-culture system of breast cancer by citing the example of the analysis of intratumoral estrogen production in human breast cancer. In human breast cancer tissues, aromatase has been reported to be predominantly detected in intratumoral stromal cells including adipocytes [4,5,42]. The human aromatase expression is regulated through the alternative use of multiple exons 1 [43].
Aromatase, breast cancer and obesity: A complex interaction
2012, Trends in Endocrinology and MetabolismCitation Excerpt :These groups demonstrated significantly elevated levels of estrone, estrone sulfate and estradiol in breast tumor tissue compared with circulating levels [52–54]. Several groups consistently found increased aromatase enzyme activity and mRNA levels in breast fat adjacent to the cancer tissue compared with distal fat or disease-free breast adipose tissue [17,21,45,46,55–57]. In vivo evidence from a transgenic mouse model revealed that aromatase overexpression in breast tissue was sufficient for maintaining hyperplasia in the absence of circulating estrogen and that aromatase inhibitors abrogated hyperplasia [58].
Hormone therapy and breast cancer
2011, Bulletin du Cancer