Elsevier

Thrombosis Research

Volume 46, Issue 5, 1 June 1987, Pages 625-633
Thrombosis Research

Paper
Relationship between age and plasma t-PA, PA-inhibitor, and PA activity

https://doi.org/10.1016/0049-3848(87)90264-7Get rights and content

Abstract

A positive correlation between age and the occurrence of thrombosis has been suggested. We studied the relationship between age and fibrinolytic activities; namely levels of tissue plasminogen activator (t-PA) antigen, plasminogen activator inhibitor (PA inhibitor) activity, and plasminogen activator activity (PA activity). A dramatic increase in both t-PA antigen and PA inhibitor was shown in persons with increasing age. PA activity decreased with age. Therefore it is suggested that the tendency of decreased PA activity with increasing age may be related to the high incidence of thrombosis in older persons.

References (28)

  • N. Bergsdorf et al.

    An enzyme linked immunosorbent assay for determination of tissue plasminogen activator applied to patients with thromboembolic disease

    Thrombos. Haemostas.

    (1983)
  • E.J.P. Brommer et al.

    Masking of fibrinolysic response to stimulation by an inhibitor of tissue-type plasminogen activator in plasma

    Thrombos. Haemostas.

    (1984)
  • J.H. Verheijen et al.

    A simple, sensitive speetrophotometric assay for extrinsic (tissue-type) plasminogen activator applicable to measurements in plasma

    Thrombos. Haemostas.

    (1982)
  • T. Hovig et al.

    Platelet adherence to fibrin and collagen

    J. Lab. Clin. Med.

    (1968)

    • Cited by (0)

    View full text
    Copyright © 1987 Published by Elsevier Ireland Ltd.