Scientific articleRenal cell carcinoma in young andold patients Comparison of prognostic pathologic variables (cell type, tumor grade and stage, and DNA ploidy pattern) and their impact on disease outcome
References (14)
- et al.
Renal cell carcinoma: long-term survival and late recurrence
J Urol
(1981) - et al.
Renal carcinoma in adolescents
J Urol
(1979) - et al.
Well differentiated clear cell renal carcinoma: significance of nuclear deoxyribonucleic acid patterns studied by flow cytometry
J Urol
(1987) Convention on nomenclature for DNA cytometry
Committee on Nomenclature, Society for Analytical Cytology, Cancer Genet Cytogenet
(1984)- et al.
Renal adenocarcinoma in young adults: survival and variables affecting prognosis
J Urol
(1981) Classification of renal neoplasms: a clinical and pathological study based on 199 cases
J Urol
(1944)- et al.
The significance of cytoplasmic granularity in the prognosis of renal cell carcinoma
J Urol
(1965)
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Efficacy of targeted therapy for metastatic renal cell carcinoma in the elderly patient population
2014, Clinical Genitourinary CancerCitation Excerpt :Older individuals constitute a large proportion of patients with RCC, with a median age at diagnosis of 60 years.2 The pathophysiology of RCC might vary with age, because older patients might present with increased prevalence of VHL mutations and a greater frequency of clear cell histology.3-5 Furthermore, older individuals have decreased liver and renal function, potentially affecting the drug metabolism of most of the small-molecule targeted agents reliant on the cytochrome P450 system and drugs dependent on renal excretion.6-9
Renal Cell Carcinoma in Young and Old Patients-Is There a Difference?
2008, Journal of UrologyCitation Excerpt :We also observed that younger patients are more likely to be symptomatic at presentation despite having tumors of similar size compared with those in their older counterparts, which is also supported by previous observations.1–3 Of the 8 published retrospective comparisons between patients with RCC who were younger than 40 years and older patients 5 included all patients older than 40 years,2,4–7 while the remaining 3 included patients 58 to 61,3 60 to 701 and older than 79 years.8 In this study we compared patients younger than 40 years to patients 40 to 59 and 60 to 79 years old, and further evaluated age as a continuous variable.
Renal Cell Carcinoma in Adults 40 Years Old or Less: Young Age is an Independent Prognostic Factor for Cancer-Specific Survival{A figure is presented}
2007, European UrologyCitation Excerpt :However, early forms of colon and breast cancers in young adults have already been investigated [11–14] and based on those findings, these tumours, though rare in people under age 40, seem to have a more pejorative prognosis and therefore require more aggressive therapeutic management than that usually prescribed for older patients. To date, the rare studies on early-onset RCC, at or before 40 yr of age, have been mostly descriptive, and sometimes comparative, but most of the time involved small numbers of patients, relatively short follow-up, or a singular control group (Table 1) [3–7,10,15–20]. For most of those authors, RCC in young adults had the same prognostic factors compared to those identified in older patients and their tumours, at the time of diagnosis, were at a lower stage with apparently a better prognosis.
Incidental renal cancer in young adults: Clinical and histopathological findings
2007, Actas Urologicas Espanolas
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Department of UrologyMayo Clinic Rochester, Minnesota 55905