Cell
ArticleThe midbrain-hindbrain phenotype of mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum
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2024, Annals of AnatomyApoptosis is involved in maintaining the character of the midbrain and the diencephalon roof plate after neural tube closure
2020, Developmental BiologyCitation Excerpt :The ANR and the RP formed from the neural plate border via NTC also act as a signaling center to regulate development of the neural tube by secreting morphogen Wnts, especially Wnt-1 and/or Wnt-3a in a region-specific manner (Chizhikov and Millen, 2005). Wnt-1 is essential in the formation of the midbrain and the hindbrain as well as in dorsal specification of the spinal cord and the neural crest cells (Chizhikov and Millen, 2005; Ikeya et al., 1997; McMahon and Bradley, 1990; McMahon et al., 1992; Muroyama et al., 2002; Shimamura et al., 1994; Shinozuka et al., 2019). It was reported that no obvious differences were found in the generation of the neural crest cells between the trunk and the hindbrain regions of apoptosis-deficient, Apaf1 mutant embryos (Massa et al., 2009), while few studies addressed the effects of apoptosis on the RP of the cranial regions.
Rspo1 and Rspo3 are required for sensory lineage neural crest formation in mouse embryos
2024, Developmental DynamicsEngrailed: Pathological and physiological effects of a multifunctional developmental gene
2024, Genesis (United States)