Cell
Volume 69, Issue 2, 17 April 1992, Pages 265-273
ArticleAbnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis
References (58)
- et al.
Genetic analysis of mammalian GAP expressed in yeast
Cell
(1989) - et al.
The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins
Cell
(1990) - et al.
A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations
Cell
(1990) Ras C-terminal processing enzymes—new drug targets?
Cell
(1991)- et al.
Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP)
J. Biol. Chem.
(1990) - et al.
Purification, characterization, and Western blot analysis of human GTPase-activating protein from native and recombinant sources
J. Biol. Chem.
(1990) ras and GAP-who's controlling whom?
Cell
(1990)- et al.
Regulation of p21ras activity
Trends Genet.
(1991) - et al.
cDNA cloning of the type 1 neurofibromatosis gene: complete sequence of the NF1 gene product
Genomics
(1991) How does p21 ras transform cells
Trends Genet.
(1991)
The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21
Cell
(1990)
S. cerevisiae genes IRA1 and IRA2 encode proteins that may be functionally equivalent to mammalian ras GTPase activating protein
Cell
(1990)
Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus
Cell
(1990)
The structure of Ras protein: a model for a universal molecular switch
Trends Biochem. Sci.
(1991)
The catalytic domain of the neurofibromatosis type-1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae
Cell
(1990)
The neurofibromatosis type-1 gene encodes a protein related to GAP
Cell
(1990)
Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain
Science
(1988)
ras genes
Annu. Rev. Biochem.
(1987)
Differential regulation of ras GAP and neurofibromatosis gene product activities
Nature
(1991)
The GTPase superfamily: a conserved switch for diverse cell functions
Nature
(1990)
The GTPase superfamily: conserved structure and molecular mechanism
Nature
(1991)
The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product
Nature
(1988)
The product of the neurofibromatosis type 1 gene is expressed at highest abundance in neurons, Schwann cells, and oligodendrocytes
Neuron
(1992)
Identification and characterization of the neurofibromatosis type 1 protein product
A ras effector domain mutant which is temperature sensitive for cellular transformation: interactions with GTPase-activating protein and NF-1
Mol. Cell. Biol.
(1991)
Inhibition of cell growth by lovastatin is independent of ras function
Cancer Res.
(1991)
Suppression of src transformation by overexpression of full-length GTPase activating protein (GAP) or of the GAP C terminus
Mol. Cell. Biol.
(1991)
Altered guanine nucleotide binding and H-ras transforming and differentiating activities
Oncogene
(1988)
Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases
Nature
(1990)
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