HNF-3β is essential for node and notochord formation in mouse development

doi:10.1016/0092-8674(94)90522-3

Cell

Volume 78, Issue 4, 26 August 1994, Pages 561-574

https://doi.org/10.1016/0092-8674(94)90522-3 Get rights and content

Abstract

HNF-3β, a member of the HNF-3/fork head family of transcription factors, is expressed in the node, notochord, floor plate, and gut in mouse embryos. A null mutation of this gene leads to embryonic lethality. The primary defect of HNF-3β^−/− embryos is an absence of organized node and notochord formation, which leads to secondary defects in dorsal-ventral patterning of the neural tube. In contrast, patterning along the anterior-posterior axis was surprisingly little affected. Although HNF-3β is required for node and notochord formation, some organizer activity persists in the absence of these structures. HNF-3β Is not required for the development of definitive endoderm cells, but foregut morphogenesis is severely affected in HNF-3β^−/− embryos.

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^∗: Present address: Centre National de la Recherche Scientifique-Laboratoire de Génétique Moléculaire des Eucaryotes, Institut National de la Santé et de la Recherche Médicale-U.184, Institut de Chimie Biologique, Faculté de Medecine, 11 rue Humann, 67085 Strasbourg Cedex, France.

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Cell

HNF-3β is essential for node and notochord formation in mouse development

Abstract

Dev. Biol.

Curr. Opin. Genet. Dev.

Cell

Cell

Meth. Enzymol.

Mech. Dev.

Cell

Mech. Dev.

Cell

Mech. Dev.

Cell

Cell

Mech. Dev.

Cell

Cell

Cell

Dev. Biol.

Cell

Cell

Anterior mesendoderm induces mouse engraded genes in explant cultures

Development

The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF-3/fork head proteins

Development

Induction of a second neural axis by the mouse node

Development

An in situ transgenic enzyme marker for the midgestation mouse embryo and the visualization of the inner cell mass clones during early organogenesis

Development

Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos

Development

Co-crystal structure of the HNF-3/fork head DNA recognition motif resembles histone H5

Nature

Examining pattern formation in mouse, chicken and frog embryos with an en-specific antiserum

Development

Formation of ectopic neurepithelium in chick blastoderms: age-related capacities for induction and self differentiation following transplantation of quail Hansen's node

Anat. Rec.

A novel, activin-inducible, blastopore lip-specific gene of Xenopus laevis contains a fork head DNA-binding domain

Genes Dev.

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J. Neurobiol.

Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1

Science

Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes

Science

Pax-3, a novel murine DNA-binding protein expressed during early neurogenesis

EMBO J.

Signals from the notochord and floor plate regulate the region-specific expression of two Pax genes in the developing spinal cord

Development

Region-specific neural induction of an engrailed protein by anterior notochord in Xenopus

Science