Philadelphia chromosome-positive adult acute leukemia with monosomy of chromosome number seven: A subgroup with poor response to therapy

doi:10.1016/0145-2126(83)90046-2

Leukemia Research

Volume 7, Issue 4, 1983, Pages 509-522

https://doi.org/10.1016/0145-2126(83)90046-2 Get rights and content

Abstract

Thirty-four adult patients were seen at the University of Texas M.D. Anderson Hospital and Tumor Institute at Houston, Texas between 1969 and 1980 with acute leukemia (AL) and a deleted G-group chromosome that was shown by Giemsa banding to be a Philadelphia (Ph¹ chromosome t(9;22) in 21 patients. Fourteen had the Ph¹ chromosome as the sole abnormality, 12 had the Ph¹ chromosome and loss of one chromosome of the C-group (identified by Giemsa banding analysis as number 7 in eight patients), while eight had the Ph¹ chromosome and other changes. These three groups were similar in sex, age distribution and hematologic parameters. The median age of 40 was lower than usually seen in AL. The distribution of the morphologic subtypes was similar to that seen at this institution, with 50% being acute myeloblastic, 12% acute myelomonocytic, 20% lymphoblastic and 18% acute undifferentiated. The complete remission rate with chemotherapy was low: 25% in the Ph¹+/−7, 50% in the Ph¹+/other group and 43% in the Ph¹+/other group. Median survival time was 8 months for the Ph¹+/−7 group, 5.5 months the Ph¹+/other group and 9.0 months for the Ph¹+/alone group. These patients with Ph¹+ AL had higher white blood cell counts, increased extramedullary disease and poorer responses to therapy than usual for patients with AL. The deletion of chromosome 7 and the acquisition of the Ph¹ chromosome identifies a group of patients with characteristics similar to all the patients with Ph¹ + AL but a poor response to therapy and short remission duration.

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^☆: This work was supported in part by Contract CA28153-02, 137117 from the National Cancer Institute, National Institute of Health, U.S. Public Health Service, Bethesda, MD 20014, U.S.A.

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Philadelphia chromosome-positive adult acute leukemia with monosomy of chromosome number seven: A subgroup with poor response to therapy☆

Abstract

Cancer Genet. Cytogenet.

Blood

Blood

Blood

Lancet

Am. J. Med.

Blood

Lancet

Blood

Clin. Hematol.

Cancer. Genet. Cytogenet.

Lancet

Lancet

Clinical implications of monosomy 7 in acute non-lymphocytic leukemia

Cancer Genet. Cytogenet.

The Philadelphia chromosome in acute leukemia

Virchows Arch. B Cell Pathol.

The philadelphia chromosome (Ph1) in adults presenting with acute leukemia: A comparison of Ph1+ and Ph1− patients

Br. J. Haematol.

Ph1-positive acute leukemia and chronic granulocytic leukemia: One or two diseases?

Br. J. Haematol.

The significance of the Philadelphia chromosome in acute lymphoblastic leukemia: A report of two cases

Br. J. Haematol.

Acute myeloid leukemia with the Philadelphia chromosome

Scand. J. Haematol.

The philadelphia chromosome (Ph¹) in adults presenting with acute leukemia: A comparison of Ph¹+ and Ph¹− patients

Ph¹-positive acute leukemia and chronic granulocytic leukemia: One or two diseases?