Repression of nuclear lamin A and C gene expression in human acute lymphoblastic leukemia and non-Hodgkin's lymphoma cells
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Cited by (49)
Aberrant nuclear lamina contributes to the malignancy of human gliomas
2022, Journal of Genetics and GenomicsCitation Excerpt :Lamin-deficient cells in vitro exhibited dysmorphic nuclei, resembling cancer cells, demonstrating their importance in cancer development (Bell and Lammerding, 2016). Lamin downregulation was reported in leukemias (Stadelmann et al., 1990) and breast (Capo-chichi et al., 2011), colon (Belt et al., 2011), and gastric cancers (Wu et al., 2009). For instance, upregulation of lamin expression was found in prostate (Leman and Getzenberg, 2002), skin (Tilli et al., 2003), ovarian (Alaiya et al., 1997), and liver cancers (Sun et al., 2010).
Unusual Presentations of LMNA-Associated Lipodystrophy with Complex Phenotypes and Generalized Fat Loss: When the Genetic Diagnosis Uncovers Novel Features
2020, AACE Clinical Case ReportsCitation Excerpt :Patient 2, on the other hand, represents the first report of lymphoma in lipodystrophy caused by a pathogenic variant of LMNA. Reduced or absent expression of nuclear lamins was reported in human malignancies (15), including leukemia and lymphomas (16). A variant similar to p.K486E, p.K486N, has previously been associated with partial lipodystrophy although no detailed description of the index patient was reported in the original paper (17).
Loss of lamin A but not lamin C expression in epithelial ovarian cancer cells is associated with metastasis and poor prognosis
2015, Pathology Research and PracticeCitation Excerpt :They were treated as an integral whole, i.e., lamin A/C, in most studies. Lamin A/C were often found to show loss of expression in cancer cells, including leukemia and lymphoma, colon cancer, gastric cancer [7–9], and EOC [10], but a few studies suggested the differential expression patterns of the two isoforms [11]. To further highlight their differential expression patterns in EOC, we explored the relationships of lamin A and lamin C expression with some clinicopathological features of the disease.
Keep-ING balance: Tumor suppression by epigenetic regulation
2014, FEBS LettersCitation Excerpt :Like aging, cancer is associated with global misregulation of gene expression [44–46], suggesting that both aging and cancer are in some aspects, developmental diseases. For example, loss of lamin A due to promoter methylation of the lamin A/C gene has been reported for hematologic malignancies [47,48]. While normal B and T cells express lamin A and ING(1), leukemia and lymphoma cells do not, nor do some normal progenitor cells or early B/T cell intermediaries [46,49].
Higher order chromatin organization in cancer
2013, Seminars in Cancer BiologyCitation Excerpt :Generally speaking, methylation patterns are dysregulated in cancer as are other chromatin modifications [58]. It has been known for some time that Lamin A is not present in some hematological malignancies and it is now understood that the promoter region of the LMNA/C gene is hypermethylated in these diseases [16,59]. More recently, while normal B and T cells express Lamin A, leukemia and lymphoma cells do not nor do some normal progenitor cells or early B/T cell intermediaries [58].
Loss of lamin A/C expression in stage II and III colon cancer is associated with disease recurrence
2011, European Journal of CancerCitation Excerpt :Signal transduction pathways influenced by lamins include Wnt- and TGFβ-signalling, which are of particular relevance to colon carcinogenesis.19 Although lamins are commonly expressed by most differentiated somatic cells, LMNA expression may be reduced in transformed cells as has been demonstrated for several tumour (sub)types, including colorectal neoplasms.10,20–25 The aim of the present study was to evaluate the protein expression of LMNA in stage II and III colon cancer tissue samples to investigate its potential as a prognostic biomarker that may aid therapy selection.