Lead articleComplex chromosomal translocations in the Philadelphia chromosome leukemias: Serial translocations or a concerted genomic rearrangement?☆
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Cited by (58)
Overview of clinical and genetic features of CML patients with variant Philadelphia translocations involving chromosome 7: A case series
2021, Leukemia ResearchCitation Excerpt :Then a second translocation occurs with an additional chromosome or chromosomes. Translocations formed by the two-step mechanism are more complex [7–9]. The variant Ph translocations may involve many other chromosomes.
Molecular cytogenetic characterization of variant Philadelphia translocations in chronic myeloid leukemia: genesis and deletion of derivative chromosome 9
2009, Cancer Genetics and CytogeneticsCitation Excerpt :Variant Ph chromosome translocations may be caused by insertion or other mechanisms [4,5]. There is open debate about the formation of these rearrangements: some researchers [6–9] have invoked a one-step mechanism, wherein chromosome breakage occurs on three different chromosomes simultaneously in a three-, four-, or five-way translocation, then reciprocally rejoin at the same time. Others [10,11] have suggested a two-step mechanism, in which a standard two-way t(9;22) is followed by subsequent translocation involving additional chromosomes, and some recent studies [3,9] have reported both mechanisms in the same patient.
Mechanisms of genesis of variant translocation in chronic myeloid leukemia are not correlated with ABL1 or BCR deletion status or response to imatinib therapy
2008, Cancer Genetics and CytogeneticsCitation Excerpt :To date, two main mechanisms in the formation of variant translocation have already been described. The one-step mechanism has been referred to a simultaneous swap among the three (or more) chromosomes involved in translocation [5,6,20]. It is illustrated by one fusion, two red, and two green signals (1F2G2R).
On the genesis and prognosis of variant translocations in chronic myeloid leukemia
2007, Cancer Genetics and CytogeneticsComplex chromosomal rearrangements in patients with chronic myeloid leukemia
2006, Cancer Genetics and CytogeneticsCitation Excerpt :Masked Ph chromosomes can be found in cases with a normal karyotype, as a result of a cryptic rearrangement, or in patients with complex changes where the typical t(9;22)(q34;q11) is not detectable by G-banding [2]. Variant Ph translocations are cytogenetically classified as simple (involving chromosome 22 and one chromosome other than 9 [3]) or complex (involving chromosomes 9, 22, and one or more other chromosomes [4]). The segment from the third chromosome is usually translocated to the band 9q34, whereas the 22q11∼qter segment (including the 3′BCR region) moves to the breakpoint of the third chromosome [5,6].
Studies of complex Ph translocations in cases with chronic myelogenous leukemia and one with acute lymphoblastic leukemia
2006, Cancer Genetics and CytogeneticsCitation Excerpt :Complex translocations may be caused by different mechanisms. Some variant translocations are formed by multiple simultaneous breaks, and some arise as a result of 2 or more consecutive genetic events [14–17]. In our series, all chromosomally abnormal cells showed the complex variant t(9;22;V) at the time of diagnosis, suggesting that it was originated in a stem cell.
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This project was supported by the Cancer Society of New Zealand, its Canterbury-Westland Division, and the WH Travis Trust.