Cytogenetic evidence for a chromosome 22 tumor suppressor gene in ependymoma☆
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Cited by (63)
Central nervous system gliomas
2017, Critical Reviews in Oncology/HematologyCitation Excerpt :Approximately two thirds of patients exhibit cytogenetic abnormalities but no primary deletion is evident. The most frequent abnormal cytogenetic features consist of monosomy 22, or in various translocations involving chromosome 22, which have been detected in approximately 30–40% of cases (Lamszus et al., 2001; Weremowicz et al., 1992; Nijssen et al., 1994; Ward et al., 2001; Lourdusamy et al., 2015). The absence of a tumour-suppressor gene located on chromosome 22 was suggested.
Primary Tumors of the Nervous System
2013, Emery and Rimoin's Principles and Practice of Medical GeneticsEpendymoma
2007, Critical Reviews in Oncology/HematologyCitation Excerpt :Approximately two thirds of patients exhibit cytogenetic abnormalities but no primary deletion is evident. The most frequent abnormal cytogenetic features consist of monosomy 22 or in various translocations involving chromosome 22, which have been detected in approximately 30% of cases [19–22]. The absence of a tumour-suppressor gene located on chromosome 22 has been suggested.
Analysis of the NF2 gene in oligodendrogliomas and ependymomas
2002, Cancer Genetics and CytogeneticsTumors of the nervous system
2015, Cancer Cytogenetics: Fourth EditionSpinal cord ependymomas and the appearance of other de novo tumors: A systematic review
2014, Journal of Medical Case Reports
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Dr. Fletcher was supported in part by Physician-Scientist Award No. 1-K11-CA-01498-02 from the National Institutes of Health.