Crystal growth of monosodium urate monohydrate

doi:10.1016/0166-6622(85)80044-5

Colloids and Surfaces

Volume 14, Issue 1, 1985, Pages 97-107

https://doi.org/10.1016/0166-6622(85)80044-5 Get rights and content

Abstract

A microscopic method has been used to measure crystal-growth rates for monosodium urate monohydrate from aqueous solution at 37°C. The dependence of the rate on supersaturation obeys a surface-nucleation law, not a screw dislocation type of law. When appropriate corrections were made, the growth rates at high sodium concentrations were in agreement with those in equimolar monosodium urate monohydrate solutions.

Extrapolation of these results to the concentration regime in which monosodium urate monohydrate precipitation in human joints leads to gout, suggests that in gout the crystals must grow slowly over a period of years.

References (22)

A.A. Khalaf et al.
J. Cryst. Growth
(1973)
C.-Y.Lam Erwin et al.
J. Cryst. Growth
(1981)
D.J. Allen et al.
J. Pharm. Sci.
(1965)
W.J.P. Van Enckevort et al.
J. Cryst. Growth
(1980)
I. Gutzow
J. Cryst. Growth
(1977)
D.E. Ovsienko et al.
J. Cryst. Growth
(1982)
A.E. Nielsen et al.
J. Cryst. Growth
(1971)
C. Rinaudo et al.
J. Cryst. Growth
(1982)
P.A. Dieppe et al.
(1983)
R.W. Fiddis et al.
Ann. Rheum. Dis. Supp. 1
(1983)

W.R. Wilcox et al.

Med. Biol. Eng.

(1972)

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Crystal growth of monosodium urate monohydrate

Abstract

J. Cryst. Growth

J. Cryst. Growth

J. Pharm. Sci.

J. Cryst. Growth

J. Cryst. Growth

J. Cryst. Growth

J. Cryst. Growth

J. Cryst. Growth

Ann. Rheum. Dis. Supp. 1

Med. Biol. Eng.