Elsevier

Immunology Today

Volume 11, 1990, Pages 400-406
Immunology Today

Review
CD4, CD8 and the TCR-CD3 complex: a novel class of protein-tyrosine kinase receptor

https://doi.org/10.1016/0167-5699(90)90159-7Get rights and content

Abstract

A novel form of receptor-kinase interaction was first described in the interaction between the CD4 and CD8 antigens and the protein tyrosine kinase p56lck. This linkage, between a regulatory antigen on T cells and a member of a family of intracellular molecules with an established ability to activate and transform cells, is likely to be of great importance in the regulation of T-cell growth. Recently, data have been obtained on the molecular basis of regulation of the CD4/CD8-p56lck interaction and an interaction between the T-cell receptor complex (TCR-CD3) and another src-kinase p59fyn has been described. Here, Christopher Rudd examines these interactions and outlines their potential roles in normal and malignant T-cell growth.

References (65)

  • E.L Reinherz et al.

    Immunol. Today

    (1983)
  • J.D Marth et al.

    Cell

    (1985)
  • J.M Trevillyan et al.

    Biochim. Biophys. Acta

    (1986)
  • J.M Turner et al.

    Cell

    (1990)
  • P.M Snow et al.

    J. Biol. Chem.

    (1983)
  • M-L Blue et al.

    Cell

    (1988)
  • D.R Kaplan et al.

    Cell

    (1987)
  • J Meisenhelder et al.

    Cell

    (1989)
  • P Marrack et al.

    Immunol. Today

    (1988)
  • C.E Rudd et al.

    Immunol. Reviews

    (1989)
  • S.L Swain

    Immunol. Rev.

    (1983)
  • K Eichmann et al.

    Eur. J. Immunol.

    (1987)
  • P Anderson et al.

    J. Immunol.

    (1987)
  • C.E Rudd et al.
  • C.E Rudd et al.
  • E.K Barber et al.
  • A Viellette et al.

    Cell

    (1988)
  • M.S Collett et al.
  • A.M Garvin et al.

    Mol. Cell. Biol.

    (1988)
  • A.F Voronova et al.

    Nature

    (1986)
  • Y Koga et al.

    Eur. J. Immunol.

    (1986)
  • K.E Amrein et al.
  • J.D Marth et al.

    EMBO J.

    (1987)
  • T Pawson

    Oncogene

    (1988)
  • H-C.R Wang et al.

    J. Virol.

    (1989)
  • A Veillette et al.

    Mol. Cell. Biol.

    (1988)
  • A.S Shaw et al.

    Cell

    (1989)
  • C.E Rudd et al.
  • R Zamoyska et al.

    Nature

    (1989)
  • M.A Vega et al.

    Eur. J. Immunol.

    (1990)
  • A.S Shaw et al.

    Mol. Cell. Biol.

    (1990)
  • F Calabi et al.

    Nature

    (1986)
  • Cited by (0)

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