clinical perspectivesImmunosuppressive therapy of autoimmune diseases
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2003, Cellular ImmunologyCitation Excerpt :Thus, the CST obscured the nosologic order inherent in the major clinical autoimmune diseases [17] and denied the very existence of physiological autoimmunity [18]. Moreover, the CST theory of self–nonself discrimination led to autoimmune disease therapies aimed at blocking specific self-recognition or designed to destroy self-reactive lymphocytes [19]. This therapeutic strategy, regrettably, has thus far failed.
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