High endothelial venules (HEVs): specialized endothelium for lymphocyte migration

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Abstract

High endothelial venules (HEVs) are specialized postcapillary venules found in lymphoid tissues that support high levels of lymphocyte extravasation from the blood. Here, Jean-Philippe Girard and Timothy Springer highlight the unique properties of HEV endothelium, discuss the molecular mechanisms controlling HEV specialization and review evidence suggesting that HEVs could play an important role in the pathogenesis of chronic inflammatory diseases.

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      Citation Excerpt :

      Across the vascular bed, morphological diversity among the ECs has been observed. In the high endothelial venules, the ECs appear to be plump [51,52]. ECs also show diversity in the context of cell thickness where it is around 0.1 μm in the veins and capillaries and 1 μm in the aorta [53].

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    1

    Jean-Philippe Girard is at the Laboratoire de Biologie Moléculaire Eucaryote (LBME) du CNRS, 118 route de Narbonne, F-31062 Toulouse, France; Timothy Springer is at the Center for Blood Research and Dept of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.

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