ReviewThe lymphocyte — a disgraceful gap in medical knowledge
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Rat immunology
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2015, A Historical Perspective on Evidence-Based ImmunologyWhole-Body Anatomy of Human T Cells
2013, ImmunityCitation Excerpt :The introduction of microscopic anatomy in the 1800s allowed a deeper understanding of organ and tissue function, but histologic stainings also had their immanent restrictions: surface molecule combinations defining an individual cell’s ontogeny and purpose are difficult to determine in (fixed) tissue sections. For this reason the role of “small lymphocytes” remained elusive (Gowans, 1996) for decades, until monoclonal antibodies and flow cytometry enabled the discrimination of more and more lymphocyte subsets on the single-cell level and helped to decipher their function for adaptive immune responses. Today state-of-the-art multicolor flow cytometry allows reliable discrimination of more than a dozen subset markers in one single sample, but this usually requires fresh ex-vivo-isolated leukocytes.
Attack the tumor counterattack-c-Flip expression in Jurkat-T-cells protects against apoptosis induced by coculture with SW620 colorectal adenocarcinoma cells
2012, Journal of Surgical ResearchCitation Excerpt :The so-called tumor-infiltrating lymphocytes (TIL) migrate to and then enter the tumor; these represent the most important, specific immune response against the tumor [3]. Various subpopulations of lymphocytes can be detected in tumor samples, including CD8+, CD4+, natural killer cells (NK), macrophages, and dendritic cells (DCs) [6–10]. During tumorigenesis, tumor cell populations first acquire properties enabling their local invasion into surrounding organ structures as well as their hematogenic and lymphatic metastasis [3, 11].
Chapter 9 Antibody specificity and diversity. The proteins (Part I)
1997, Foundations of Modern BiochemistryHigh endothelial venules: Lymphocyte traffic control and controlled traffic
1997, Advances in Immunology