Development of carbohydrate intolerance in offspring of Asian Indian conjugal type 2 diabetic parents

doi:10.1016/0168-8227(90)90126-E

Diabetes Research and Clinical Practice

Volume 8, Issue 3, 1990, Pages 269-273

https://doi.org/10.1016/0168-8227(90)90126-E Get rights and content

Abstract

Sixty-four offspring of conjugal diabetic parents (OCDP) who were normoglycaemic initially were available for a retest after a period of 4–9 years. Among them 10 (15.6%) had developed diabetes, 19 (29.7%) had developed IGT and the remaining 35 (54.7%) had maintained normal GTT. The predictive value of the baseline (initial) parameters was tested.

Among the non-obese OCDP (BMI <25 and <27 for women and men, respectively), the initial sum of plasma glucose (ΣPG), and the mean increment of insulin during GTT (ΔIRI), and the 2-h IRI values were higher in the group that developed abnormal glucose tolerance (P < 0.05 compared to controls and normal OCDP). They also had higher insulin: glucose ratios, indicating higher insulin output for a given glucose concentration. On the other hand, among the obese OCDP the initial parameters did not differ between those who developed abnormal glucose tolerance and those who did not.

Stepwise multiple regression analysis showed that the baseline Σplasma glucose value was significantly related to the final 2-h plasma glucose when all the OCDP were taken together (P = 0.0023) and also in the non-obese OCDP (P = 0.0002). The other parameter which showed a relation to the final 2-h plasma glucose was the baseline ΔIRI, although it was not statistically significant (P = 0.08). No such relation was observed in the obese group.

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Research articleDevelopment of carbohydrate intolerance in offspring of Asian Indian conjugal type 2 diabetic parents

Abstract

Prevalence of diabetes and glucose intolerance in 199 offspring of thirtyseven conjugal diabetic parents

Diabetes

High prevalence of diabetes in offspring of Indian type 2 diabetic parents in India

Diabetologia

Pancreatic beta cell function in offspring of conjugal diabetic parents. Assessment by IRI and C-Peptide ratio

Horm. Metab. Res.

II Rep. Ser. 646

Recommendations on the standardisation of methods and reporting of tests for diabetes and its microvascular complications in epidemiological studies

Diabetes Care

A specific determination of blood glucose with ortho-toluidine

Clin. Chim. Acta

Colorimetric measurement of glycosylated protein in whole blood, red blood cells, plasma and dried blood

Ann. Clin. Biochem.

Research article
Development of carbohydrate intolerance in offspring of Asian Indian conjugal type 2 diabetic parents