ReviewHepatic stellate (ITO) cells: expanding roles for a liver-specific pericyte
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Single-cell RNA transcriptome landscape of hepatocytes and non-parenchymal cells in healthy and NAFLD mouse liver
2021, iScienceCitation Excerpt :2) The identification of double ISH-stained cells of endothelial marker Ptprb and stellate cell marker Lum further confirmed the existence of chimeric cells. HSCs are considered to be liver-specific pericytes (Hellerbrand, 2013; Pinzani, 1995a, 1995b) and, like pericytes in other tissues, are physically connected with endothelial cells and directly interact with them in a reciprocal manner (Poisson et al., 2017). Further experiments are needed to test whether this subpopulation is more pericyte-like and whether they serve certain complimentary endothelial functions.
Role of nitric oxide and KATP channel in the protective effect mediated by nicorandil in bile duct ligation-induced liver fibrosis in rats
2018, Biochemical PharmacologyCitation Excerpt :PDGF and TGF-β are considered the main prompters of HSCs proliferation and activation, respectively [33,34]. These mediators participate in liver fibrosis by changing HSCs from quiescent to myofibroblast and keeping it in active form [35]. This was clearly demonstrated in the present study by a marked α-SMA expression in liver tissues of BDL group and was related to HSCs activation.
Decoding liver injury: A regulatory role for histone modifications
2015, International Journal of Biochemistry and Cell BiologyCitation Excerpt :Alteration of gene expression profiles is essential in the activation process of HSCs, in which epigenetic factors are indispensable. Cirrhosis is a hallmark of end-stage liver disease (ESLD) that results from excessive synthesis and deposition of ECM proteins (Pinzani, 1995). The epigenetic machinery regulates HSC-dependent fibrogenesis by targeting specific pro- and anti-fibrogenic factors.
Scheuer’s Liver Biopsy Interpretation
2015, Scheuer's Liver Biopsy InterpretationPericytes as the Source of Mesenchymal Stem Cells
2013, Resident Stem Cells and Regenerative TherapyLy6C<sup>+</sup> monocytes are extrahepatic precursors of hepatic stellate cells in the injured liver of mice
2011, Experimental HematologyCitation Excerpt :These results indicate that some of the adoptively transferred Ly6Chighc-kit− cells became nonhematopoietic lineage cells in the CCl4-injured liver. HpSCs are usually identified and isolated using a combination of antigenic markers, such as GFAP, desmin, CD146, vimentin, ADAMTS13, procollagen type I, and α-SMA [23–28]. We first analyzed the expression of these antigens in EGFP+ cells in the liver of mice given Ly6Chighc-kit− monocytes.