Sample size graphs for “proving the null hypothesis”
References (1)
“Proving the null hypothesis” in clinical trials
Controlled Clin Trials
(1982)
Cited by (72)
Lower and extended dosage of misoprostol for cervical ripening in 1st trimester miscarriage (MISO200): A randomized clinical trial
2022, European Journal of Obstetrics and Gynecology and Reproductive BiologyCitation Excerpt :Uterine bleeding was determined when additional measures were taken by the end of the procedure, e.g., use of intramuscular methylergometrine; cervical laceration was determined when sutures were required. Sample size was calculated according to the literature for a non-inferiority trial [18]. We expected that cervical dilatation would be achieved in 96% of the cases using 400 µg of misoprostol and 86% in the 200 µg group.
Home Management Versus Primary Care Physician Follow-up of Patients With Distal Radius Buckle Fractures: A Randomized Controlled Trial
2021, Annals of Emergency MedicineCitation Excerpt :All costs and unit prices are given in Canadian dollars (Table E1, available online at http://www.annemergmed.com). The sample size was determined with methods appropriate for noninferiority trials (ie, trials with nonzero null hypotheses).31-34 The sample size of 110 patients was based on testing the null hypothesis that home management is greater than or equal to 5% less effective than primary care physician follow-up according to the modified ASKp-38 scores at 3 weeks, α=2.5%, and having a 90% probability of rejecting the null hypothesis if home management and primary care physician follow-up are equally effective.
Randomized noninferiority field trial comparing 2 first-generation cephalosporin products at dry off in quarters receiving an internal teat sealant in dairy cows
2016, Journal of Dairy ScienceCitation Excerpt :The minimum difference in cure rate to declare noninferiority of CF compared with CP was 10% (i.e., the delta for an important difference was 10%). To demonstrate noninferiority, 275 infected quarters at S1 were needed in each group assuming α = 0.05, β = 0.1, and 80% success in the reference group (Blackwelder and Chang, 1984). Assuming 30% prevalence of infections at S1 and 10% loss to follow-up, a minimum of 255 cows per group (1,019 quarters per group) would need to be enrolled.
Comparison of antibiotic-only and antibiotic-steroid combination treatment in corneal ulcer patients: Double-blinded randomized clinical trial
2011, Canadian Journal of OphthalmologyDesigning bioequivalence studies-how much of a difference is acceptable?
2007, Fertility and Sterility
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