Alloimmunization to Platelet antigen HPA-1a (PIA1) is strongly associated with both HLA-DRB3∗0101 and HLA-DQB1∗0201
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Cited by (117)
Preclinical evaluation of immunotherapeutic regimens for fetal/neonatal alloimmune thrombocytopenia
2021, Blood AdvancesCitation Excerpt :Whether milk-derived anti-HPA-1a alloantibodies are able to mediate persistent postnatal thrombocytopenia in this animal model of FNAIT is an important, and perhaps clinically relevant, area for future investigation. The development of an immune response to HPA-1a is one of the most MHC-restricted examples of alloimmunity in humans4,45-49; >92% of HPA-1b/b mothers who develop anti-HPA-1a antibodies express at least 1 HLA DRB3*01:01 class II allele. It is worth noting that BALB/c mice (H-2 I-Ad, I-Ed) dependably developed a robust response to the APLDQ humanized form of murine GPIIIa (Figure 2), but C57BL/6 mice (H-2 I-Ab, I-Enull) barely responded at all (not shown).
Progress and development of platelet antibody detection
2020, Transfusion and Apheresis ScienceImmune-Mediated Cytopenia in the Pediatric Setting
2020, Immunologic Concepts in Transfusion MedicineAlloantibodies and Platelets
2020, Immunologic Concepts in Transfusion MedicineFoetal and neonatal alloimmune thrombocytopenia
2019, Best Practice and Research: Clinical Obstetrics and Gynaecology
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