In-depth reviewCryoglobulinemic glomerulonephritis: A membranoproliferative glomerulonephritis induced by hepatitis C virus
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2013, Manson's Tropical Diseases: Twenty-Third EditionExpression of macrophage markers in cryoglobulinemic glomerulonephritis - A possible role of CXCL9
2013, Advances in Medical SciencesCitation Excerpt :Cryoglobulinemic glomerulonephritis (CGGN) is a type of membranoproliferative glomerulonephritis (MPGN) that develops due to glomerular deposition of immune complexes in patients with systemic cryoglobulinemia (CG). Most commonly the CGGN is associated with hepatitis C infection [1,2] and contributes to the significant impairment of renal function [3]. Based on experimental animal models it was shown that the immune complex mediated injury in MPGN is multifarious and involves number of pathways, such as activation of complement cascade [4,5], engagement of Fc receptors for immunoglobulins, [6] growth factors (PDGF, TGF-ß) [7] and regulators of renal fibrosing injury (such as TGF-ß and regulators of plasmin: PN-1, tPA, PAI-1 [8–10]).
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