Bilateral electrodermal activity depressive patients

doi:10.1016/0301-0511(78)90050-9

Biological Psychology

Volume 6, Issue 2, March 1978, Pages 111-120

https://doi.org/10.1016/0301-0511(78)90050-9 Get rights and content

Abstract

Integrated bilateral skin conductance response and reactive lateral eye movements were studied in 19 depressive patients and 14 normal subjects during visual and verbal tasks and tone habituation sequence. Distinct right-left differences between depressed and normal subjects in reactive lateral eye movements were revealed. Both endogenous and reactive derpession patients were classified as ‘left-movers’. Marked bilateral differenceswere observed in electrodermal activity (EDA) in patients during verbal and visual tasks. In endogenous depression EDA was higher on the left hand compared with the right under all the conditions studied (visual and verbal, and tone habituation sequence). In reactive depression EDA was higher on the left side during the verbal task and tone habituation sequence and on the right side in the visual task. Neither result in reactive depression group attained significance. The results are interpreted as a reflection of a different pathophysiology underlying reactive and endogenous depression.

References (28)

J.W. Brown et al.
Hypothesis on cerebral dominance
Neuropsychologia
(1975)
G. Gainotti
Emotional behavior and hemispheric side of the lesion
Cortex
(1972)
D. Galin et al.
Asymmetry in evoked potentials as an index of lateralized cognitive processes: Relation to EEG alpha-asymmetry
Neuropsychologia
(1975)
J.H. Gruzelier
Bilateral asymmetry of skin conductance orienting activity and levels in schizophrenics
Biological Psychology
(1973)
M. Myslobodsky et al.
Bilateral electrodermal activity in waking man
Acta Psychologica
(1977)
P. Bakan
Hypnotizability, laterality of eye movements and functional brain asymmtry
Perceptual and Motor Skills
(1969)
M.A. Davidson et al.
Brainstem loci for activation of electrodermal response in the cat
American Journal of Physiology
(1975)
d'Elia et al.
Cerebral dominance and memory functions. An analysis of EEG integrated amplitude in depressive psychotics
Acta Psychiatrica Scand., Suppl.
(1974)
S. Fisher
Body image and asymmetry of body reactivity
The Journal of Abnormal and Social Psychology
(1958)
P. Flor-Henry
Psychosis and temporal lobe epilepsy: A controlled investigation
Epilepsia
(1969)

J. Gruzelier et al.

Bimodal and lateral asymmetry of skin conductance orienting activity in schizophrenics: Replication and evidence of lateral asymmetry in patients with depression and disorders of personality

Biological Psychiatry

(1974)

H. Hecaen et al.

Le Cecite Psychique

(1963)

F.A. Holloway et al.

Unilateral brain damage and bilateral skin conductance levels in humans

Psychophysiology

(1969)

J. Levy et al.

Perception of bilateral chimeric figures following hemispheric deconnection

Brain

(1972)

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^☆: Partially supported by a grant no. 015.9256 from the Psychobiological Society of Israel. Thanks are due to Dr. E. Lefkifker and Dr. DeMedina for their help with selection of patients and to I. Gilat for assistance in data processing. We express our appreciation to the critical reading and suggestions of Dr. B. Lubow and Dr. M. Weiner.

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Bilateral electrodermal activity depressive patients☆

Abstract

Neuropsychologia

Cortex

Neuropsychologia

Biological Psychology

Acta Psychologica

Hypnotizability, laterality of eye movements and functional brain asymmtry

Perceptual and Motor Skills

Brainstem loci for activation of electrodermal response in the cat

American Journal of Physiology

Cerebral dominance and memory functions. An analysis of EEG integrated amplitude in depressive psychotics

Acta Psychiatrica Scand., Suppl.

Body image and asymmetry of body reactivity

The Journal of Abnormal and Social Psychology

Psychosis and temporal lobe epilepsy: A controlled investigation

Epilepsia