Elsevier

Neuroscience Letters

Volume 80, Issue 2, 23 September 1987, Pages 207-212
Neuroscience Letters

The catecholamine uptake inhibitor nomifensine depresses impulse activity of dopamine neurons in mouse substantia nigra

https://doi.org/10.1016/0304-3940(87)90655-0Get rights and content

Abstract

Systemic administration of the catecholamine uptake inhibitor nomifensine (NOM) in doses of 20–36 mg/kg strongly depressed the discharge rate of dopamine (DA) neurons in the substantia nigra of mice for more than 2–3 h. This effect was fully reverted by the systemically administered DA receptor antagonist haloperidol. Impulse activity of most neurons showed a reduced rhythmicity under the influence of NOM, as assessed by autocorrelograms. It is suggested that the depression of discharge activity of DA neurons by NOM represents an indirect agonist action on the DA receptor, probably via reduced elimination of DA from the extraneuronal space.

Cited by (13)

View all citing articles on Scopus
View full text