Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immune-brain communication

https://doi.org/10.1016/0304-3940(94)11105-RGet rights and content

Abstract

Interleukin-1β (IL-1β), a cytokine released by activated immune cells, elicits various illness symptoms including hyperthermia. Previous hypotheses to account for these actions have focused on blood-borne IL-1β exerting its effects directly at the level of the brain. However, recent behavioral and physiological evidence suggest that IL-1β can activate the subdiaphragmatic vagus. The present experiments demonstrate that subdiaphragmatic vagal transection disrupts the hyperthermia-inducing effects of recombinant human IL-1β and stress. These data provide evidence for a novel route of immune-brain communication, as well as a novel route whereby stress can influence physiological processes.

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Supported by Synergen, Inc., NH Grants MH45045 and NS31569, and Hughes Undergraduate Research Initiative.

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