Review
Overexpression of genes in health and sickness. A bird's eye view

https://doi.org/10.1016/0305-0491(95)00055-DGet rights and content

Abstract

Many human disorders are associated with gene alterations, such as translocations, deletions, insertions, inversions, rearrangements and point mutations. However, an overexpression of certain normal genes could also contribute to the pathology of neurological disorders, retinal degeneration, diabetes, fibrosis of lung, cardiac and skin, programmed cell death and cancer. This implies that the regulated expression of normal genes is an important factor in determining human health. An understanding of the mechanisms involved in the control of expression of normal genes may provide a greater or more refined success in correcting, delaying or possibly preventing the disorders by a gene therapeutic approach.

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