The massive expression of c-Fos protein in spinal dorsal horn neurons is not followed by long-term changes in spinal nociception
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Cited by (42)
Effects of simulated weightlessness on intramuscular hypertonic saline induced muscle nociception and spinal Fos expression in rats
2015, Brain ResearchCitation Excerpt :Thus, it could be appropriate to speculate that only a weak, if any, ongoing barrage exists in nociceptive nerve fibers 24 h after the i.m. injection of a bolus of 0.2 ml 5.8% saline in the present animal study. It has been reported that exposure to noxious stimulation may produce changes in spinal Fos expression that fail to produce matching long-term changes in pain behavior (Bullitt et al., 1992; Sandkühler et al., 1996). The results of Fos expression in the current study are consistent with other studies showing that Fos expression returns to the basal level 8–24 h following noxious stimulation of short duration (Hunt et al., 1987; Herdegen et al., 1992; Jergova et al., 2002).
Functions of the temporomandibular system in extracranial chronic pain conditions: Modulatory effects on nocifensive behavior in an animal model
2014, Journal of Manipulative and Physiological TherapeuticsAmylin suppresses acetic acid-induced visceral pain and spinal c-fos expression in the mouse
2010, NeuroscienceCitation Excerpt :The distribution of irAMY fibers overlaps with the same regions of spinal cord expressing c-fos upon noxious stimulation. Alternatively, glutamate acting on NMDA receptors or substance P may trigger c-fos expression in the rat spinal cord (Sandkuhler et al., 1996; Badie-Mahdavi et al., 2001). Viewed in this context, amylin may inhibit c-fos expression in the dorsal horn cells by modulating the release of mediators such as glutamate and/or substance P.
Angiotensin III modulates the nociceptive control mediated by the periaqueductal gray matter
2009, NeuroscienceCitation Excerpt :The PAG is a key relay station in the processing of nociceptive and antinociceptive information in the CNS (Behbehani, 1995; Mitsui et al., 2003). The electrical stimulation of the vl subdivision of PAG produces pure antinociception in rats (Fardin et al., 1984), and depresses the response of spinal cord neurons to peripheral noxious stimulation (Sandkuhler et al., 1996), whereas persistent noxious stimulation increases PAG activity (Monhemius et al., 2001). The tail-flick to noxious heat of the skin is a spinal reflex.