Does prolactin play a role in skin biology and pathology?
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Cited by (41)
Clinical efficacy of propylthiouracil and its influence on prolactin in psoriatic patients
2011, Clinical BiochemistryCitation Excerpt :An elevated level of PRL was observed in both male and female psoriatic patients. Our result is in accordance with previous findings [13,15,38,39]. PTU treatment decreased the level of PRL significantly in a duration dependent manner.
Prolactin: An emerging force along the cutaneous-endocrine axis
2010, Trends in Endocrinology and MetabolismCitation Excerpt :These effects are evident in women with hyperprolactinemia, who develop hirsutism and seborrhea, not uncommonly associated with female pattern balding [13]. Patients treated with hyperprolactinemia-inducing neuroleptic agents also develop seborrhea [9], but the mechanism of PRL-induced seborrhea remains unclear. As sebocytes are prominent target cells of neuroendocrine signaling [61], PRL might also contribute to the aggravating effect of psychoemotional stress on acne vulgaris.
Mind the (Gender) Gap: Does prolactin exert gender and/or site-specific effects on the human hair follicle
2010, Journal of Investigative DermatologyProlactin and the skin: A dermatological perspective on an ancient pleiotropic peptide hormone
2009, Journal of Investigative DermatologyCitation Excerpt :For example, PRL's prominent role in lower vertebrate skin osmoregulation and its putative function in the regulation of human sweat gland activities raise the question of whether PRL is also important in hyperhidrosis, another condition greatly influenced by psychoemotional stress. The psoriasis-promoting effects of PRL summarized above have also invited the speculation that PRL is part of the elusive systemic factor that underlies the Koebner phenomenon in psoriasis (Paus, 1991). The pilosebaceous unit harbors many additional pointers to the “PRL–skin connection.”
Dermatologic manifestations of hypopituitarism
2006, Clinics in Dermatology