International Journal of Radiation Oncology*Biology*Physics
Original contributionTests for the fit of the linear-quadratic model to radiation isoeffect data☆
References (11)
Dose fractionation, dose rate and isoeffect relationships for normal tissue responses
Int. J. Radial. Oncol. BioL Phys.
(1982)- et al.
Dependence of RBE on fraction size for negative pi-meson induced renal Injury
Int. J. Radial. Oncol. Biol. Phys.
(1981) - et al.
Accelerated fractionation vs hyperfractionation: rationales for several treatments per day
Int. J. Radial. Oncol. Biol. Phys.
(1983) - et al.
Changes in early and late radiation responses with altered dose fractionation: implications for dose-survival relationships
Int. J. Radial. Oncol. Biol. Phys.
(1982) - et al.
Flexure dose: the lowdose limit of effective fractionation
Int. J. Radial. Oncol. Biol. Phys.
(1983)
Cited by (61)
Radiation pneumonitis after hypofractionated radiotherapy: Evaluation of the LQ(L) model and different dose parameters
2010, International Journal of Radiation Oncology Biology PhysicsCitation Excerpt :Consequently, clinical questions concerning normal tissue tolerance dose and the possibility of including multiple targets or irradiating larger lung volumes (e.g., applying multiple treatments or irradiation of larger tumors) are important. For conventional fractionated radiotherapy, the physical dose can be converted into a biological equivalent dose by using the linear quadratic (LQ) model (1, 2). Historically, the strength of the LQ model for conventional fraction doses is twofold.
Radiation pneumonitis in patients treated for malignant pulmonary lesions with hypofractionated radiation therapy
2009, Radiotherapy and OncologyCitation Excerpt :However, no lung dose characteristics were reported, and RP risk estimating could therefore not be performed. To predict normal tissue complication probabilities (NTCPs) after radiotherapy treatment, the delivered dose has to be recalculated into a biological-effective dose using a mathematical model (linear quadratic model) [35,36] derived from in vitro and animal studies [37]. The clinical applicability of this model is a historical cornerstone in assessing tumour doses and dose tolerance of normal tissues in conventional fractionation schemes.
The Linear-Quadratic Model Is an Appropriate Methodology for Determining Isoeffective Doses at Large Doses Per Fraction
2008, Seminars in Radiation OncologyCitation Excerpt :Extensive Fe plot analyses by Barendsen,24 using 12 normal tissue response endpoints, reached the same conclusion. Although more sophisticated methods are available for assessing agreement with the LQ model,30, given the inherent uncertainties in the data, it is clear that all these data, including those for single fractions of ∼20 Gy, are consistent with the LQ model. We have shown that the LQ model is reasonably predictive of dose-response relations, both in vitro and in vivo, in the dose per fraction range of 2 to 15 Gy.
Radiation tolerance of the rat spinal cord after 6 and 18 fractions of photons and carbon ions: Experimental results and clinical implications
2006, International Journal of Radiation Oncology Biology PhysicsCitation Excerpt :This hypothesis, however, could not be proven in this study. Iso-effect relations may be used to graphically determine the value of α/β (33, 36, 37). These relations, however, use correlated variables and a reliable estimate of the involved confidence limits is difficult.
Capacity and kinetics of SLD repair in mouse tongue epithelium
1993, Radiotherapy and OncologyLinear-quadratic model underestimates sparing effect of small doses per fraction in rat spinal cord
1992, Radiotherapy and Oncology
- ☆
Supported in part by Grants CA-29026, CA-11430, and CA-06294 from the National Cancer Institute, National Institutes of health.