International Journal of Radiation Oncology*Biology*Physics
Brief communicationReversal of cranial nerve dysfunction with radiation therapy in adults with lymphoma and leukemia☆
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Cited by (25)
Radiotherapeutic palliation of bone marrow diseases—leukemia and multiple myeloma
2023, Palliative Radiation OncologyCraniospinal irradiation prior to stem cell transplant for hematologic malignancies with CNS involvement: Effectiveness and toxicity after photon or proton treatment
2017, Practical Radiation OncologyCitation Excerpt :Radiation therapy is increasingly recognized as efficacious for the treatment of central nervous system (CNS) disease in hematologic malignancy patients, primarily leukemia.1 Although the natural history of leukemia/lymphoma has been known to include CNS disease,2,3 recent advances in therapy leading to overall improved hematologic malignancy outcomes have increased the rates of patients presenting with this therapeutic challenge, primarily from poor CNS penetrance of cytotoxic and targeted therapy agents.4,5 Although leukemia and lymphoma involving the CNS is generally associated with poor prognosis,4-6 a prior study demonstrated that whole brain or craniospinal irradiation (CSI) still conferred a 12-month CNS progression-free survival rate of 77% in patients affected with acute leukemia.1
Comprehensive craniospinal radiation for controlling central nervous system leukemia
2014, International Journal of Radiation Oncology Biology PhysicsCitation Excerpt :With the increasing number of patients who undergo multiple salvage regimens and thus survive multiple systemic relapses, CNS relapse and its treatment have emerged as important components of the disease course (7-10). Previous work has been done to clarify the symptoms of CNS leukemia and the benefit of RT; however, little information exists regarding extent of the optimal RT field (11-14). To control CNS disease, RT can be focused on the base of skull, the whole brain, or the entire craniospinal axis.
Leptomeningeal Metastasis
2007, Current Problems in CancerCitation Excerpt :Focal RT has been successful at relieving pain, focal weakness, sensory loss, bowel/bladder dysfunction, focal seizures, cranial nerve palsies, and CSF flow abnormalities.122 If RT is delivered early enough and appropriately directed, neurologic abnormalities can sometimes be reversed.121,123 In one study, over two-thirds of patients receiving RT experienced regression of neurological symptoms either during or within days after RT was completed.124
Primary meningeal lymphoma of T-cell origin: A rare presentation of primary central nervous system lymphomas
2007, Clinical Lymphoma and MyelomaUnusual variants of primary central nervous system lymphoma
2005, Hematology/Oncology Clinics of North America
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Presented at the American Society for Therapeutic Radiation Oncology, San Francisco, CA, October 1989.