Neuropeptide Y immunoreactivity in the hamster geniculo-suprachiasmatic tract

doi:10.1016/0361-9230(85)90037-1

Brain Research Bulletin

Volume 15, Issue 5, November 1985, Pages 465-472

https://doi.org/10.1016/0361-9230(85)90037-1 Get rights and content

Abstract

The distributions of neuropeptide Y (NPY) and avian pancreatic polypeptide (APP) immunoreactivity were examined in the suprachiasmatic nucleus and the geniculate area of male golden hamster brains. In some cases, colchicine was injected intraventricularly to aid in visualization of immunoreactive cell bodies. A group of hamsters were given bilateral or unilateral radiofrequency lesions of the geniculate area and neuropeptide Y immunoreactivity was examined in the suprachiasmatic nucleus after survival times varying between 8 and 300 days. Another group of hamsters received unilateral intraocular injections of anterograde tracers and the overlap of NPY-immunoreactive cells in the geniculate area and labeled retinal afferents was assessed. It was found that NPY- and APP-immunoreactive fibers formed a dense plexus in the ventro-lateral suprachiasmatic nucleus. NPY-immunoreactive cell bodies were observed in the intergeniculate leaflet as well as in the external lamina of the anterior portion of the ventral lateral geniculate nucleus. Unilateral lesions of the geniculate produced a relative reduction in neuropeptide Y immunoreactivity in the ipsilateral suprachiasmatic nucleus whereas bilateral lesions produced a reduction of neuropeptide Y immunoreactivity in both suprachiasmatic nuclei. All NPY-immunoreactive cells in the intergeniculate leaflet were overlapped by bilateral retinal afferents. In the ventral lateral geniculate nucleus, all NPY-immunoreactive cells were overlapped by contralateral retinal afferents; however, not all such cells were in areas receiving ipsilateral retinal afferents. These results indicate that the hamster geniculo-suprachiasmatic tract originates in part from NPY-immunoreactive cell bodies and that these cells lie in areas receiving direct retinal afferents.

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Neuropeptide Y immunoreactivity in the hamster geniculo-suprachiasmatic tract

Abstract

Neurosci Lett

Brain Res

Neuroscience

Physiol Behav

Neuroscience

Brain Res

Neurosci Lett

Brain Res

Brain Res

Brain Res

Neuroscience

Brain Res

Brain Res

Neuroscience

Brain Res

Neurosci Res

Avian pancreatic polypeptide phase shifts hamster circadian rhythms when microinjected into the suprachiasmatic region

Science

Neuropeptide Y distribution in the rat brain

Science

Circadian phase response curves for dark pulses in the hamster

J Comp Physiol

Ventral lateral geniculate nucleus efferents to the rat suprachiasmatic nucleus exhibit avian pancreatic polypeptide-like immunoreactivity

J Comp Neurol

An immunocytochemical study of the serotonergic innervation of the thalamus of the rat

J Comp Neurol

An axonal transport study of the ascending projection of medial lemniscal neurons in the rat

J Comp Neurol

Visuo-cerebellar and cerebello-visual connections involving the ventral lateral geniculate nucleus

Exp Brain Res