Methadone dose and treatment outcome☆
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Cited by (106)
Effects of medication assisted treatment (MAT) for opioid use disorder on functional outcomes: A systematic review
2018, Journal of Substance Abuse TreatmentCitation Excerpt :However, 50 mg methadone was significantly more effective than placebo (MD −2.50 days; CI −7.63, −2.63). Comparing the number of crimes committed, both 20 mg (MD 4.0 fewer crimes) and 50 mg (MD 9.23 fewer crimes) methadone were significantly more effective than the placebo (Strain et al., 1993). Another RCT that randomized 111 offenders with OUD to receive oral naltrexone with standard psychological treatment or standard psychological treatment alone (control) reported no significant difference between groups in the average number of charges (MD-0.30 fewer charges) or convictions per month (MD 0.00 fewer charges; SD not reported; Coviello et al., 2010).
A randomized investigation of methadone doses at or over 100mg/day, combined with contingency management
2013, Drug and Alcohol DependenceCitation Excerpt :The average methadone dose in community clinics has increased over the past few decades, with the proportion of patients receiving doses <80 mg decreasing from 94% in 1988 to 56% in 2005 (Maddux et al., 1991; D’Aunno and Vaughn, 1992; D’Aunno et al., 1999; D’Aunno and Pollack, 2002; Pollack and D’Aunno, 2008), and prior outside approval of doses over 100 mg/day is no longer required (Rettig and Yarmolinsky, 1995). The trend toward higher doses has been supported by clinical trials and by retrospective analyses of outcome in clinical populations (Caplehorn and Bell, 1991; Strain et al., 1993; Maremmani et al., 1994; Hartel et al., 1995; Ling et al., 1996; Schottenfeld et al., 1997; Strain et al., 1999; Farré et al., 2002). A Cochrane review of randomized trials found that higher doses of methadone (60–100 mg/day) were more effective than lower doses (1–39 mg/day) in reducing heroin use (Faggiano et al., 2003).
Dual Disorder Heroin Addicts: Clinical and Therapeutical Aspects
2023, Dual Disorder Heroin Addicts: Clinical and Therapeutical AspectsThe Cannabis-Dependent Relationship Between Methadone Treatment Dose and Illicit Opioid Use in a Community-Based Cohort of People Who Use Drugs
2023, Cannabis and Cannabinoid Research
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Presented at: The 53rd Annual Scientific Meetifang of the Committee on Problems of Drug Dependence, Palm Beach, Florida, June 20, 1991.