Molecular cloning of two novel rab genes from human melanocytes
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Cited by (41)
Engagement of the small gtpase rab31 protein and its effector, early endosome antigen 1, is important for trafficking of the ligand-bound epidermal growth factor receptor from the early to the late endosome
2014, Journal of Biological ChemistryCitation Excerpt :The human genome contains over 60 different Rab and Rab-like genes (10, 11). Rab31 was first cloned from human melanocyte cDNA and has been classified under the Rab5-related subfamily on the basis of sequence homology (12). The Rab5 subfamily of Rab proteins includes Rab5, Rab21, Rab22a, and Rab31 (13).
Defective RAB31-mediated megakaryocytic early endosomal trafficking of VWF, EGFR, and M6PR in RUNX1 deficiency
2022, Blood AdvancesCitation Excerpt :At least 40 Rab proteins are recognized in human platelets,4 but specific roles in vesicle trafficking are unknown in platelets or megakaryocytes for the majority. RAB31 (Ras-related protein in brain 31), a member of the RAB5 subfamily of Rab GTPases, was cloned from human platelets,5 and it shared ∼82% homology with RAB22B protein identified in human melanocytes.6 RAB31 regulates anterograde and retrograde membrane trafficking between the Golgi/trans-Golgi network (TGN) and the endosomes and plasma membrane.3,7,8
Rab22a promotes the proliferation, migration, and invasion of lung adenocarcinoma via up-regulating PI3K/Akt/mTOR signaling pathway
2022, Experimental Cell ResearchCitation Excerpt :Rab22a, a small GTPase with a molecular weight of 22KD, belongs to the Rab5 subfamily. Like Rab5, Rab22a is also an indispensable small GTPase in the regulation of early endocytosis by participating in the formation, transportation, and fusion of vesicles [7,8]. Recently, studies had shown that Rab22a was overexpressed in various malignant tumors and plays a pro-oncogenic role, such as in ovarian cancer [9], osteosarcoma [10], nasopharyngeal carcinoma [11], and melanoma [12].
A role for Rab30 in retrograde trafficking and maintenance of endosome-TGN organization
2021, Experimental Cell ResearchCitation Excerpt :RAB30 was originally discovered from cDNA extracted from human melanocytes and was mapped to chromosome 11 [1,2]. The RAB30 sequence contains the generic isoprenylation sequence (CCAAX) allowing for physical attachment to the membrane bilayer through a geranylgeranyl lipid anchor [1]. Rab30 has been shown to be required for embryo development in Drosophila melanogaster [3], although the function of this small G protein still remains unclear.
Characterization of RIN3 as a guanine nucleotide exchange factor for the Rab5 subfamily GTPase Rab31
2011, Journal of Biological ChemistryJNK signalling influences intracellular trafficking during Drosophila morphogenesis through regulation of the novel target gene Rab30
2009, Developmental BiologyCitation Excerpt :We focused on the poorly characterised Rab GTPase family gene Rab30, which we identified with an upregulation of 1.5-fold in Hepact expressing embryos. Rab30 was originally identified in human cells and found to be expressed widely and localised to the Golgi (Chen et al., 1996; de Leeuw et al., 1998). The human and Drosophila homologues share 63% protein identity, although the C-terminus differs quite significantly between the two proteins (Fig. 1A).