Elsevier

Maturitas

Volume 4, Issue 4, December 1982, Pages 291-299
Maturitas

The pharmacology of oestriol

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Abstract

The potency ratio of oestriol compared to oestradiol or to ethinyloestradiol depends on the experimental conditions of the test. If a sufficiently high level of oestriol is maintained in a target tissue, either by infusion or by frequent administration, this steroid is capable of eliciting a full oestrogenic effect. At the target tissue, oestriol is a short-acting rather than a weak-acting oestrogen. This explains why certain oestrogenic effects are not observed after a single administration of oestriol or after far-spaced dosings. The short retention time of oestriol in the target tissues makes the oestrogenic effects dependent on the manner of administration of the compound, in particular on the route of administration and on the frequency of dosing.

References (16)

  • B.S. Katzenellenbogen et al.

    Estrogens and antiestrogen action in reproductive tissues and tumors

  • G.F. Marrian

    LII. The chemistry of oestrin, III. An improved method of preparation and the isolation of active crystalline material

    Biochem. J.

    (1930)
  • E.A. Doisy et al.

    A new triatomic alcohol from the urine of pregnant women

  • J.S.L. Browne
  • C.W. Emmens et al.

    Estrogens

  • F.L. Hisaw et al.

    Interaction of estrogens on uterine growth

    J. Clin. Endocrinol. Metab.

    (1954)
  • A. Puck et al.

    Die Wirkungen des Oestriols auf Uterus und Vagina des Kaninchens und Meerschweinchens und auf die Symphyse des Meerschweinchens

    Acta Endocrinol.

    (1956)
  • G.A. Overbeek et al.

    A comparison of oestriol and oestradiol in the female rat

    Acta Endocrinol.

    (1958)
There are more references available in the full text version of this article.

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