Age-related changes in cochleas of mongolian gerbils
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The crucial role of diverse animal models to investigate cochlear aging and hearing loss
2024, Hearing ResearchHidden hearing loss: Fifteen years at a glance
2024, Hearing ResearchSpeech sound discrimination by Mongolian gerbils
2022, Hearing ResearchCitation Excerpt :Besides their suitability as a model in hearing research, gerbils are also suitable subjects for studying the effects of aging on physiological functions, because they only live three to four years (Cheal, 1986). Moreover, old gerbils show increased auditory thresholds, age-related deficits in the representation of temporal structures of sounds and characteristics of strial and neural presbycusis (Gleich et al., 2016; Hamann et al., 2002; Heeringa et al., 2020; Hellstrom and Schmiedt, 1990; Kessler et al., 2020; Laumen et al., 2016; Tarnowski et al., 1991). Consequently, they have been used to study age-related hearing loss and its different structural and functional aspects (Gleich and Strutz, 2012).
Age-related decline in cochlear ribbon synapses and its relation to different metrics of auditory-nerve activity
2021, Neurobiology of AgingCitation Excerpt :It has a short lifespan, good low-frequency hearing sensitivity, and the peripheral pathology is similar in many aspects to the human condition in the absence of noise damage (Cheal, 1986; Heeringa and Köppl, 2019; Gates and Mills, 2005; Ryan, 1976). Specifically, old gerbils show synapse loss (Gleich et al., 2016), spiral-ganglion cell loss (Keithley et al., 1989), and a lower EP due to strial dysfunction (Schmiedt et al., 2002a); the loss of hair cells is, however, minimal (Tarnowski et al., 1991). The reduction in synapse number in old, compared to young-adult, gerbils was reported to be nearly 40% in the apical, low-frequency, cochlear region, while it was relatively small in the middle and basal regions (11%–17%).
Age-related loss of auditory sensitivity in the zebrafish (Danio rerio)
2021, Hearing ResearchCitation Excerpt :Postmortem examination of human tissue has provided important insight on morphological characteristics of ARHL (e.g. Schukneckt, 1964), but fundamental constraints on mechanistic research with human subjects – paired with the complex etiology of ARHL and confounding population variables such as noise exposure (e.g., Liberman, 2017) – have necessitated the use of animal model systems for experimental studies of ARHL. To date, numerous studies have leveraged non-human mammalian models to investigate ARHL, and the use of such model systems has greatly contributed to our understanding of its causes and mechanisms (Schuknecht, 1955; Bhattacharyya and Dayal, 1989; Mills et al., 1990; Tarnowski et al., 1991; Ohlemiller, 2004; Dubno et al., 2013; Jiang et al., 2015; Bowl and Dawson, 2019). While non-mammalian vertebrate model systems have proven complementary to mammalian models in other domains of translational auditory research, relatively few studies have examined effects of advanced age on auditory function in non-mammalian vertebrates, and little is known about the incidence or extent of such.