Endolumph volume changes during osmotic dehydration measured by two marker techniques
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Cited by (23)
Communication pathways to and from the inner ear and their contributions to drug delivery
2018, Hearing ResearchCitation Excerpt :Charged substances can also be highly influenced by the EP. As a result of the EP, anions such as the marker AsF6− are drawn in (Salt and DeMott, 1995) while cationic markers (TMPA+) and ions such as Na+ are driven out through the non-specific cation channels in the apical membranes of hair cells (Kros et al., 1992) and of outer sulcus cells (Kim and Marcus, 2011). Additional efflux of Na+ occurs through epithelial sodium channels in the apical membranes of cells in Reissner's membrane (Kim and Marcus, 2011).
Endolymph movement visualized with light sheet fluorescence microscopy in an acute hydrops model
2016, Hearing ResearchCitation Excerpt :However, as pointed out by Salt (2001), the process of injecting a fluid marker itself induces fluid flow. Studies where fluid markers have been iontophoresed without volume disturbances demonstrate the almost complete lack of endolymph ‘flow’ (Salt and DeMott, 1995). That's not to say the results of studies which injected fluid markers in volume should be dismissed, but rather they should be interpreted in regards to endolymph dynamics under non-physiological or ‘disturbed’ conditions, such as that which occurs with endolymphatic hydrops.
Evaluation of the effects of phototherapy on cochlear function in newborns
2014, International Journal of Pediatric OtorhinolaryngologyCitation Excerpt :Taking all of these factors into consideration, it is inevitable that changes in osmolarity will affect outer hair cells. Dehydration causes a decrease in the extent of scala media [13]. According to Suckfull et al. [14], increased serum osmolarity leads to marked disturbances in outer hair cell function.
Water channel proteins in the inner ear and their link to hearing impairment and deafness
2012, Molecular Aspects of MedicineCitation Excerpt :However, if the endolymph volume is significantly increased, a longitudinal endolymph flow from the apex to the base of the cochlear duct can occur with the conclusion that outside of the cochlea the ES may play a role in the correction of endolymph volume increase (Salt and DeMott, 1997). Conversely, a longitudinal endolymph flow from the base to the apex of the cochlear duct arises when the endolymph volume is decreased by osmotically induced dehydration (Salt and DeMott, 1995). These observations suggest that longitudinal endolymph movements appear exclusively under pathophysiological conditions in which constant endolymph volume and ionic balance are compromised and cannot be compensated by local, radial homeostasis.
Endolymphatic Hydrops: Pathophysiology and Experimental Models
2010, Otolaryngologic Clinics of North AmericaCitation Excerpt :In the normal ear, basal turn endolymph is slightly hypertonic with respect to perilymph and with respect to endolymph of the apical turns. This difference occurs even though the water permeability between endolymph and perilymph is high (equilibration half-time 7.6 minutes).46,47 The hyperosmolarity can be accounted for by the biophysical concept of the “reflection coefficient” in which the osmotic activity of a solute depends on its permeability through the membrane dividing compartments.
The subcellular distribution of aquaporin 5 in the cochlea reveals a water shunt at the perilymph-endolymph barrier
2010, NeuroscienceCitation Excerpt :However, it has been demonstrated that in the normal state of cochlear function, longitudinal endolymphatic volume flow does not occur to a significant degree and, therefore, may not be involved in the maintenance of ion and water concentrations of inner ear fluid spaces (Salt and DeMott, 1995). Manipulations of endolymph volume led to an apically directed endolymph flow induced by a reduction of endolymphatic volume (Salt and DeMott, 1995), whereas volume flow directed to the base of the endolymphatic fluid compartment was observed after increasing the endolymph volume (Salt and DeMott, 1997). Therefore, longitudinal endolymph flow may occur in response to endolymph volume disturbances.