Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study

doi:10.1016/0378-8741(91)90167-C

Journal of Ethnopharmacology

Volume 33, Issues 1–2, May–June 1991, Pages 91-95

https://doi.org/10.1016/0378-8741(91)90167-C Get rights and content

Abstract

The clinical efficacy of a herbomineral formulation containing roots of Withania somnifera, the stem of Boswellia serrata, rhizomes of Curcuma longa and a zinc complex (Articulin-F), was evaluated in a randomized, double-blind, placebo controlled, cross-over study in patients with osteoarthritis. After a one-month single blind run-in period, 42 patients with osteoarthritis were randomly allocated to receive either a drug treatment or a matching placebo for a period of three months. After a 15-day wash-out period the patients were transferred to the other treatment for a further period of three months. Clinical efficacy was evaluated every fortnight on the basis of severity of pain, morning stiffness, Ritchie articular index, joint score, disability score and grip strength. Other parameters like erythrocyte sedimentation rate and radiological examination were carried out on a monthly basis. Treatment with the herbomineral formulation produced a significant drop in severity of pain (P < 0.001) and disability score (P < 0.05). Radiological assessment, however, did not show any significant changes in both the groups. Side effects observed with this formulation did not necesitate withdrawal of treatment.

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In a 2-week-long double-blind crossover study in rheumatoid arthritis patients there were remarkable antiinflammatory effects observed [124,125]. In another 6-month-long clinical study in osteoarthritis patients curcumin reduced the pain and severity of health issue [125,126]. Similarly another single-blind clinical study extending for 42 days reported significant reduction in the scores of VAS, WOMAC, and CGIC [125,127].
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Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study

Abstract

Antiinflammatory activity of Withania somnifera

Indian Journal of Experimental Biology

Antiinflammatory studies on Curcuma longa

Indian Journal of Medical Research

Pharmacology of Withania somnifera — A review

Indian Drugs

Long term effects of herbal drug Withania somnifera on adjuvant induced arthritis in rats

Indian Journal of Experimental Biology

Review of biological activity of Withanolides

Journal of Scientific and Industrial Research

Antiinflammatory and antiarthritic activity of volatile oil of Curcuma longa

Indian Journal of Medical Research

Charak Samhita

Renal syndromes associated with nonsteroidal antiinflammatory drugs

New England Journal of Medicine

Preliminary study of antiarthritic activity of curcumin

Indian Journal of Mecical Research

Guide To Good Manufacturing Practice

Chemicatry and pharmacology of gum-resin of Boswellia serrata

Indian Drugs

Osteoarthritis: Pathophysiology, clinical features and management

Hospital Practice

Efficacy of Articulin Forte in arthropathies

Effect of Ashwagandha on the process of ageing in human volunteers

Journal of Research in Ayurveda and Sidda

Radiographic evaluation of rheumatoid arthritis and associated conditions by standard reference film

Acta Radiologica Diagnosis

Screening of antirheumatic drugs

Analgesic and psychopharmacological effects of gum-resin of Boswellia serrata

Planta Medica